Ghatge Anjali Sharad, Ghatge Sharad Balasaheb
Department of Dermatology, Apollo Clinic, Mumbai, 400001, India.
Department of Radiology, Sir JJ Group of Hospitals and Grant Government Medical College, Mumbai, 400008, India.
Clin Cosmet Investig Dermatol. 2023 Apr 4;16:891-899. doi: 10.2147/CCID.S404248. eCollection 2023.
Several studies have evaluated the role of various injectable formulations of hyaluronic acid (HA) in the improvement of the quality of facial skin. It is important to systematically summarize the available evidence in this regard.
Relevant databases were searched for clinical studies that evaluated the therapeutic role of any injectable formulation of HA in improving the quality of facial skin in adult humans until 31 December 2022. The available studies were critically analyzed and the data were extracted.
A total of 2996 articles were screened and 13 studies were finally included. Eight studies evaluated the effect of various formulations of HA alone, while five evaluated the effect of various formulations of HA along with other active ingredients (cocktails) on the quality of facial skin. All types of HA formulations cause a significant improvement in facial skin quality, in terms of hydration, firmness, skin-tiring effect/fatigue, brightness, texture, radiance, and elasticity. The effect of HA monotherapy was more pronounced than that of the cocktail ingredients. HA treatment was quite safe and the patient satisfaction level was high.
The clinical evidence on the use of injectable HA alone in the improvement of the quality of facial skin, in terms of hydration, firmness, skin-tiring effect/fatigue, brightness, texture, radiance, and elasticity, is quite promising. Large randomized controlled trials are required in this regard.
多项研究评估了透明质酸（HA）的各种注射制剂在改善面部皮肤质量方面的作用。系统总结这方面的现有证据很重要。
检索相关数据库，查找截至2022年12月31日评估HA的任何注射制剂在改善成年人类面部皮肤质量方面治疗作用的临床研究。对现有研究进行严格分析并提取数据。
共筛选出2996篇文章，最终纳入13项研究。8项研究评估了单独使用各种HA制剂的效果，而5项研究评估了各种HA制剂与其他活性成分（组合配方）对面部皮肤质量的影响。所有类型的HA制剂在保湿、紧致度、皮肤疲劳效应/疲劳感、亮度、质地、光泽和弹性方面均能显著改善面部皮肤质量。HA单一疗法的效果比组合配方成分更显著。HA治疗相当安全，患者满意度高。
就保湿、紧致度、皮肤疲劳效应/疲劳感、亮度、质地、光泽和弹性而言，单独使用注射用HA改善面部皮肤质量的临床证据很有前景。在这方面需要进行大型随机对照试验。
