Dukharan Victoria, Shah Milaan, Broughton Luke, Stegura Carol, Samman Luna, Schur Nina, Schlesinger Todd
J Cosmet Dermatol. 2025 Jan;24(1):e16761. doi: 10.1111/jocd.16761.
Exosomes are extracellular vesicles, composed of a phospholipid bilayer, that are primarily derived from stem cells. The contents of exosomes can be incorporated into the tissue in which they are introduced, which presents a unique therapeutic option.
Exosomes have been investigated as a treatment for a number of medical ailments, but the literature supporting these indications is inconclusive. In addition, much of the study on exosomes and their uses has been recently completed. Thus, this review summarizes the efficacy and implications of exosomes in the treatment of different dermatologic conditions.
A literature review surrounding the use of exosomes for multiple medical dermatological conditions was conducted. Additionally, we present numerous practical cases in which patients had been treated with exosomes.
Overall, the success of exosomes in treating medical dermatologic conditions demonstrated varying efficacy in the literature, but the preliminary evidence is generally positive. The patient cases also showed satisfactory clinical outcomes but further studies and cases will be necessary to fully characterize the efficacy of exosomes and the ideal modalities for their application, including formulation, mode of distribution, and frequency of treatment.
Exosomes may serve as an effective treatment option for wound healing, reconstruction of skin flaps, radiation dermatitis, acne vulgaris, psoriasis, atopic dermatitis, allergic contact dermatitis, lichen simplex chronicus, vulvar lichen sclerosis, systemic sclerosis, systemic lupus erythematosus, and vitiligo although additional studies are needed to confirm their efficacy and safety.
外泌体是由磷脂双分子层组成的细胞外囊泡，主要来源于干细胞。外泌体的内容物可被整合到其被引入的组织中，这提供了一种独特的治疗选择。
外泌体已被研究用于治疗多种医学疾病，但支持这些适应症的文献尚无定论。此外，关于外泌体及其用途的许多研究最近才完成。因此，本综述总结了外泌体在治疗不同皮肤病中的疗效及意义。
围绕外泌体在多种医学皮肤病中的应用进行了文献综述。此外，我们还展示了许多使用外泌体治疗患者的实际病例。
总体而言，外泌体在治疗医学皮肤病方面的成功在文献中显示出不同的疗效，但初步证据总体上是积极的。患者病例也显示出令人满意的临床结果，但需要进一步的研究和病例来充分描述外泌体的疗效及其理想的应用方式，包括制剂、给药方式和治疗频率。
外泌体可能是伤口愈合、皮瓣重建、放射性皮炎、寻常痤疮、银屑病、特应性皮炎、过敏性接触性皮炎、慢性单纯性苔藓、外阴硬化性苔藓、系统性硬化症、系统性红斑狼疮和白癜风的有效治疗选择，尽管还需要更多研究来证实其疗效和安全性。
