Shah Milaan, Dukharan Victoria, Broughton Luke, Stegura Carol, Schur Nina, Samman Luna, Schlesinger Todd
J Cosmet Dermatol. 2025 Jan;24(1):e16766. doi: 10.1111/jocd.16766.
Exosomes are nanoscale vesicles derived from various cell types and tissues that have many potential applications, generating great interest from researchers. One particularly intriguing application of exosomes is their use as a direct therapeutic for aesthetic indications. Several studies and case reports have explored the impact of exosomes for numerous cosmetic concerns but a consensus on the outcomes of these studies has not been established.
In this review, we summarize the proposed mechanism of action, application, and efficacy of treatments with exosomes for alopecia and hair rejuvenation, facial rejuvenation, hyperpigmentation, and scarring.
We conducted a comprehensive literature review on the use of exosomes for the treatment of alopecia and hair rejuvenation, facial rejuvenation, hyperpigmentation, and scarring. Additionally, several practical clinical cases where exosomes were applied for these indications were included.
The general consensus from the literature review showed that the early evidence supports the efficacy of exosomes for the treatment of alopecia, facial rejuvenation, hyperpigmentation, and scarring. The clinical cases included demonstrated promising improvements in the patients that received treatment. Several limitations regarding the lack of standardization in the production and application of exosomes may limit their current use until more studies are conducted.
Exosomes may serve as a potentially beneficial therapeutic option for several aesthetic dermatologic indications but further investigation is required to fully characterize the scope of their application.
外泌体是源自各种细胞类型和组织的纳米级囊泡，具有许多潜在应用，引起了研究人员的极大兴趣。外泌体一个特别引人关注的应用是将其用作美容适应症的直接治疗方法。多项研究和病例报告探讨了外泌体对众多美容问题的影响，但尚未就这些研究的结果达成共识。
在本综述中，我们总结了外泌体用于治疗脱发和头发年轻化、面部年轻化、色素沉着和瘢痕形成的作用机制、应用及疗效。
我们对外泌体用于治疗脱发和头发年轻化、面部年轻化、色素沉着和瘢痕形成进行了全面的文献综述。此外，还纳入了一些将外泌体应用于这些适应症的实际临床病例。
文献综述的总体共识表明，早期证据支持外泌体用于治疗脱发、面部年轻化、色素沉着和瘢痕形成的疗效。所纳入的临床病例显示接受治疗的患者有显著改善。外泌体生产和应用缺乏标准化的一些局限性可能会限制其目前的使用，直到进行更多研究。
外泌体可能是几种美容皮肤科适应症的潜在有益治疗选择，但需要进一步研究以充分确定其应用范围。
