Zanardi Stefano, Sabattini Silvia, Rossi Federica, Rossanese Matteo, Buracco Paolo, Montinaro Vincenzo, Aralla Marina, Dentini Alfredo, Pizzi Elisa, Volpe Enrico, Tremolada Giovanni, Marconato Laura
Department of Veterinary Medical Sciences, University of Bologna, Ozzano dell'Emilia, Bologna, Italy.
Anicura Clinica Veterinaria dell'Orologio, Bologna, Italy.
Vet Comp Oncol. 2025 Jun;23(2):161-167. doi: 10.1111/vco.13041. Epub 2025 Jan 11.
Adjuvant chemotherapy is a well-established treatment for large-breed dogs with appendicular osteosarcoma; however, it is unclear if it improves outcomes in small-breed dogs due to limited focused studies. This retrospective study aimed to investigate the oncologic outcomes of dogs weighting less than 15 kg with appendicular osteosarcoma that underwent curative resection with or without postoperative adjuvant chemotherapy. Endpoints were time to distant progression (TTDP) and overall survival (OS). Medical records from multiple institutions were reviewed, and 43 dogs were included in the analysis: 17 underwent surgery alone and 26 also received adjuvant chemotherapy. The median TTDP for all dogs was 265 days, with no significant difference between treatment groups. The median OS for all dogs was 270 days, and it was significantly different between amputated dogs (150 days) and those also receiving adjuvant chemotherapy (353 days, p = 0.002). In our cohort, osteosarcoma in small breeds behaved as aggressive as in large breeds. Adjuvant chemotherapy may prolong survival. Future randomised studies are needed to provide definitive evidence on the necessity of adjuvant chemotherapy to address metastatic spread in small-breed dogs with appendicular osteosarcoma.
辅助化疗是大型犬附肢骨肉瘤的一种成熟治疗方法；然而，由于针对性研究有限，尚不清楚其是否能改善小型犬的治疗结果。这项回顾性研究旨在调查体重小于15千克的附肢骨肉瘤犬接受根治性切除并接受或未接受术后辅助化疗的肿瘤学结局。终点指标为远处转移时间（TTDP）和总生存期（OS）。对多个机构的病历进行了回顾，43只犬被纳入分析：17只仅接受手术，26只还接受了辅助化疗。所有犬的中位TTDP为265天，各治疗组之间无显著差异。所有犬的中位OS为270天，截肢犬（150天）与接受辅助化疗的犬（353天，p = 0.002）之间存在显著差异。在我们的队列中，小型犬的骨肉瘤表现与大型犬一样具有侵袭性。辅助化疗可能会延长生存期。未来需要进行随机研究，以提供关于辅助化疗对治疗小型犬附肢骨肉瘤转移扩散必要性的确切证据。
