Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio.
Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois.
Vet Surg. 2020 Aug;49(6):1154-1163. doi: 10.1111/vsu.13470. Epub 2020 Jun 20.
To determine outcome and prognostic factors in small breed dogs in which hemangiosarcoma was diagnosed and whether outcomes differed between small and large breed dogs with splenic hemangiosarcoma.
Bi-institutional retrospective study.
Forty-three small breed (<20 kg) and 94 large breed client-owned dogs.
Medical records were reviewed to identify dogs treated with splenectomy for splenic hemangiosarcoma. Data acquired included signalment, preoperative staging, bloodwork results, surgical findings, histopathologic findings, administration of chemotherapy, presence/absence of metastatic disease, and survival time (ST). Cox proportional hazards regression analysis was performed to assess prognostic factors associated with survival.
The overall median ST was 116 days and 97 days for small and large breed dogs, respectively. The ST for dogs treated with surgery and chemotherapy was 207 and 139 days for small and large breed dogs, respectively. The disease-free interval (DFI) was 446 and 80 days for small and large breed dogs, respectively. Dog size was associated with DFI (P = .02) but not with ST (P = .09). The presence of metastasis at diagnosis was associated with decreased ST in small (P = .03) and large (P = .0009) breed dogs. Administration of chemotherapy (P = .02) was associated with increased ST (P = .02) in small breed dogs.
The ST was not different in small and large breed dogs with splenic hemangiosarcoma treated with splenectomy and chemotherapy.
Prognosis remains poor despite aggressive therapies in small and large breed dogs.
确定小型犬诊断为血管肉瘤的结果和预后因素，以及是否存在小型犬和大型犬脾血管肉瘤的预后差异。
机构间回顾性研究。
43 只小型（<20kg）和 94 只大型品种犬。
回顾性分析接受脾切除术治疗脾血管肉瘤的犬的病历。获取的资料包括一般信息、术前分期、血液检查结果、手术发现、组织病理学发现、化疗管理、转移疾病的存在/缺失情况和生存时间（ST）。采用 Cox 比例风险回归分析评估与生存相关的预后因素。
小型犬的总中位 ST 为 116 天，大型犬为 97 天。接受手术和化疗治疗的小型犬和大型犬的 ST 分别为 207 天和 139 天。小型犬和大型犬的无病间隔（DFI）分别为 446 天和 80 天。犬的体型与 DFI 相关（P =.02），但与 ST 无关（P =.09）。诊断时存在转移与小型犬（P =.03）和大型犬（P =.0009）的 ST 缩短有关。化疗的应用（P =.02）与小型犬的 ST 延长相关（P =.02）。
接受脾切除术和化疗治疗的小型和大型犬脾血管肉瘤的 ST 无差异。
尽管采用了积极的治疗方法，小型犬和大型犬的预后仍然较差。
