FF-ATP酶生物分子马达：结构、运动操控及生物医学应用

FF-ATPase Biomolecular Motor: Structure, Motility Manipulations, and Biomedical Applications.

作者信息

Zhou Xuhui, Sun Miao, Yang Xiu, Shao Mengliu, Jin Mengya, She Yuanbin, Yang Qingliang, Yang Gensheng

机构信息

College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, Zhejiang, PR China.

Department of Pharmacy, Jinhua Municipal Central Hospital, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua 321000, Zhejiang, PR China.

出版信息

Biomacromolecules. 2025 Feb 10;26(2):773-786. doi: 10.1021/acs.biomac.4c01553. Epub 2025 Jan 11.

DOI:10.1021/acs.biomac.4c01553

PMID:39797787

Abstract

Biomolecular motors are dynamic systems found in organisms with high energy conversion efficiency. FF-ATPase is a rotary biomolecular motor known for its near 100% energy conversion efficiency. It utilizes the synthesis and hydrolysis of ATP to induce conformational changes in motor proteins, thereby converting chemical energy into mechanical motion. Given their high efficiency, autonomous propulsion capability, and modifiable structures, FF-ATPase motors have attracted significant attention for potential biomedical applications. This Review aims to introduce the detailed structure of FF-ATPase, explore various motility manipulation strategies, and summarize its applications in biological detection and cargo delivery. Additionally, innovative research methods are proposed to analyze the motion mechanism of FF-ATPase more comprehensively, with the goal of advancing its biomedical applications. Finally, this Review concludes with key insights and future perspectives.

摘要

生物分子马达是存在于生物体中的动态系统，具有很高的能量转换效率。F₀F₁ - ATP合酶是一种旋转生物分子马达，以其近乎100%的能量转换效率而闻名。它利用ATP的合成与水解来诱导马达蛋白的构象变化，从而将化学能转化为机械运动。鉴于其高效率、自主推进能力和可修饰的结构，F₀F₁ - ATP合酶马达在潜在生物医学应用方面引起了广泛关注。本综述旨在介绍F₀F₁ - ATP合酶的详细结构，探索各种运动操纵策略，并总结其在生物检测和货物递送中的应用。此外，还提出了创新的研究方法，以更全面地分析F₀F₁ - ATP合酶的运动机制，目的是推动其生物医学应用。最后，本综述以关键见解和未来展望作为总结。