铕离子掺杂的钼酸锶钙钛矿量子点作为一种用于同时检测次黄嘌呤生物标志物和铁离子的关-开型荧光传感器。
Eu-ion doped strontium molybdate perovskite quantum dots as a turn-off-on fluorescent sensor for simultaneous detection of hypoxanthine biomarker and Fe ions.
作者信息
Patel Mayurkumar Revabhai, Basu Hirakendu, Park Tae Jung, Kailasa Suresh Kumar
机构信息
Department of Chemistry, Sardar Vallabhbhai National Institute of Technology, Surat, Gujarat, 395 007, India.
Analytical Chemistry Division, Bhabha Atomic Research Center, Trombay, Mumbai, 400085, India.
出版信息
Mikrochim Acta. 2025 Jan 11;192(2):67. doi: 10.1007/s00604-025-06957-w.
A fluorescence "turn-off-on" nanoprobe is designed by using europium-doped strontium molybdate perovskite quantum dots (Eu:SMO PQDs) for the sequential detection of hypoxanthine (Hx) and Fe. The Eu:SMO PQDs were prepared by the sol-gel method using Sr(NO), (NH)MoO.4HO, and Eu(OCOCH) as precursors. The green fluorescence of Eu:SMO PQDs was efficiently reduced (turn-off) in the presence of Hx, then it was restored (turn-on) gradually by introducing Fe due to the competitive formation of Hx@Fe, which results to the release of Eu:SMO PQDs. In addition, the fluorescent probe exhibits excellent selectivity and sensitivity. Under the optimized experimental conditions, linear ranges and detection limits were 0.25-25 μM and 12.30 nM for Hx and 0.025-50 μM and 10.44 nM for Fe , respectively. Furthermore, the fluorescence method was successfully explored to detect Hx and Fe in plasma and urine samples.
通过使用铕掺杂钼酸锶钙钛矿量子点（Eu:SMO PQDs）设计了一种荧光“关-开”纳米探针，用于顺序检测次黄嘌呤（Hx）和铁。Eu:SMO PQDs采用溶胶-凝胶法，以Sr(NO)、(NH)MoO·4H₂O和Eu(OCOCH)为前驱体制备。在Hx存在下，Eu:SMO PQDs的绿色荧光被有效降低（关闭），然后由于Hx@Fe的竞争性形成导致Eu:SMO PQDs释放，通过引入铁使其荧光逐渐恢复（开启）。此外，该荧光探针具有优异的选择性和灵敏度。在优化的实验条件下，Hx的线性范围和检测限分别为0.25 - 25 μM和12.30 nM，铁的线性范围和检测限分别为0.025 - 50 μM和10.44 nM。此外，该荧光方法成功用于检测血浆和尿液样品中的Hx和铁。
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