Zhang Zhiling, Kwok Ryan T K, Yu Yong, Tang Ben Zhong, Ng Ka Ming
Department of Chemical and Biological Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
J Mater Chem B. 2018 Jul 28;6(28):4575-4578. doi: 10.1039/c8tb00803e. Epub 2018 Jun 29.
Hypoxanthine is a well-known indicator of intracellular energy status that is associated with many pathological conditions. We report a fluorescent luminogen (TPE-HPro) with aggregation-induced emission (AIE) feature which, along with xanthine oxidase (XO), detects and quantifies hypoxanthine in a "turn-on" manner. The superior detection performance of this fluorometric assay indicates its great potential for biomedical diagnostics.
次黄嘌呤是一种与许多病理状况相关的细胞内能量状态的知名指标。我们报道了一种具有聚集诱导发光（AIE）特性的荧光发光体（TPE-HPro），它与黄嘌呤氧化酶（XO）一起，以“开启”方式检测和定量次黄嘌呤。这种荧光测定法的卓越检测性能表明其在生物医学诊断方面具有巨大潜力。
