Zhang Muqiu, Liu Xinyao, Ran Xin, Gao Runyan, Sun Jitong, Zhuang Kaiwen, You Zimeng, Zhang Zhi, Ran Yuping
Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, China; Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.
Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, China; Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China; Laboratory of Pathogen Research, West China Hospital, Sichuan University, Chengdu, China.
Photodiagnosis Photodyn Ther. 2025 Feb;51:104467. doi: 10.1016/j.pdpdt.2024.104467. Epub 2025 Jan 9.
Skin dysbiosis caused by Cutibacterium acnes contributes greatly to the complex pathogenesis of acne, and antimicrobial photodynamic therapy (PDT) has emerged as a promising treatment option for acne treatment. Hypocrellin, a photosensitizer extracted from a traditional Chinese medicinal fungus, has showed effective antimicrobial activity. This study aimed to evaluate the antibacterial ability of hypocrellin mediated PDT against Cutibacterium acnes. Using modified broth dilution method and morphological observation, the antibacterial effect was tested under a series of experimental conditions. The results showed that hypocrellin initiates type II photodynamic reactions by inducing amount of reactive oxygen species, particularly singlet oxygen. Within a certain concentration range, hypocrellin effectively maintained the antibacterial efficacy with minimal damage to keratinocyte cells. These results provide new insights into the use of PDT for acne treatment.
痤疮丙酸杆菌引起的皮肤微生物群落失调在痤疮复杂的发病机制中起很大作用，而抗菌光动力疗法（PDT）已成为一种有前景的痤疮治疗选择。竹红菌素是从一种传统中药真菌中提取的光敏剂，已显示出有效的抗菌活性。本研究旨在评估竹红菌素介导的光动力疗法对痤疮丙酸杆菌的抗菌能力。采用改良肉汤稀释法和形态学观察，在一系列实验条件下测试抗菌效果。结果表明，竹红菌素通过诱导大量活性氧，特别是单线态氧引发II型光动力反应。在一定浓度范围内，竹红菌素有效维持抗菌效果，对角质形成细胞的损伤最小。这些结果为光动力疗法用于痤疮治疗提供了新的见解。
