Decker Franziska M, Jelinek Jonas, Korb Katharina, Fogaing Kamgaing Franck, Alam Mesbah, Krauss Joachim K, Hermann Elvis J, Schwabe Kerstin
Department of Neurosurgery, Hannover Medical School, Carl-Neuberg-Straße 1, Hannover 30625, Germany; Center for Systems Neuroscience (ZSN) Hannover, Hannover 30559, Germany.
Department of Neurosurgery, Hannover Medical School, Carl-Neuberg-Straße 1, Hannover 30625, Germany.
Behav Brain Res. 2025 Mar 28;482:115428. doi: 10.1016/j.bbr.2025.115428. Epub 2025 Jan 9.
The three-class oddball paradigm allows to investigate the processing of behaviorally relevant and irrelevant auditory stimuli. In humans, event-related potentials (ERPs) are used as neural correlate of behavior. We recorded local field potentials (LFPs) within the medial prefrontal cortex (mPFC) in rats during three-class and passive two-class oddball paradigms and analyzed the ERPs focusing on similarities to human recordings.
Rats were trained in a three-class auditory oddball paradigm to respond by nose poke to an infrequent Target tone that was rewarded, while ignoring an infrequent Distractor and frequent Standard tone of different frequencies. After reaching a success criterion of correct responses to the Target and correct rejection of the Standard and Distractor (80 %, each), electrodes were stereotaxically implanted into the mPFC. The recording of the neuronal activity took place in the three-class oddball paradigm as well as in a passive two-class oddball paradigm with unfamiliar frequencies.
Correct responding to the Target tone was accompanied by a higher amplitude of the ERP in comparison to the Standard and Distractor tones (p < 0.05). Target Miss, or incorrect responding to Distractor or Standard led to reduced, respectively enhanced peak latency. In the two-class oddball paradigm, the amplitude of the Distractor ERP was enhanced as compared to that after Standard (p < 0.05).
ERPs derived from mPFC LFPs of rats show key characteristics similar to that derived from human EEGs. This model allows to investigate the processing of behaviorally important and irrelevant auditory stimuli in subcortical brain regions in a translational approach.
三类Oddball范式可用于研究行为相关和不相关听觉刺激的处理过程。在人类中，事件相关电位（ERP）被用作行为的神经关联指标。我们在大鼠的内侧前额叶皮质（mPFC）中记录了三类和被动两类Oddball范式下的局部场电位（LFP），并分析了ERP，重点关注与人类记录的相似性。
对大鼠进行三类听觉Oddball范式训练，使其通过鼻戳对罕见的目标音调做出反应，该目标音调会得到奖励，同时忽略罕见的干扰音和不同频率的常见标准音。在对目标的正确反应以及对标准音和干扰音的正确拒绝达到成功标准（各80%）后，将电极立体定位植入mPFC。神经元活动记录在三类Oddball范式以及具有不熟悉频率的被动两类Oddball范式中进行。
与标准音和干扰音相比，对目标音调的正确反应伴随着更高的ERP振幅（p < 0.05）。目标未命中，或对干扰音或标准音的错误反应分别导致峰值潜伏期缩短或延长。在两类Oddball范式中，与标准音后相比，干扰音ERP的振幅增强（p < 0.05）。
大鼠mPFC LFP衍生的ERP显示出与人类脑电图衍生的ERP相似的关键特征。该模型允许以转化的方法研究皮质下脑区中行为重要和不相关听觉刺激的处理过程。
