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Clinical evaluation of the histochemical diagnosis of Hirschsprung's disease.

作者信息

Barr L C, Booth J, Filipe M I, Lawson J O

出版信息

Gut. 1985 Apr;26(4):393-9. doi: 10.1136/gut.26.4.393.

DOI:10.1136/gut.26.4.393
PMID:3979911
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1432504/
Abstract

The histochemical staining of suction rectal biopsies for acetylcholinesterase (AChE) activity is a safe and accurate diagnostic tool in the management of patients with symptoms and signs of Hirschsprung's disease. In this study 101 patients who have undergone AChE analysis of suction rectal biopsies are presented in order to correlate histochemical findings with subsequent clinical course after a minimum of 18 months follow up. There were no false positive results, but the limitations and problems associated with the technique which we have encountered are discussed. Equivocal, atypical, or negative results when contradicting clinical features are indications for repeat biopsy or full thickness biopsy, and awareness of the situations in which false negative results may occur is essential.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b59/1432504/8d4fe3f159e8/gut00377-0085-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b59/1432504/a63135046334/gut00377-0083-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b59/1432504/3ab71edfee68/gut00377-0083-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b59/1432504/43feb8ac1e79/gut00377-0084-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b59/1432504/3fe060cc931f/gut00377-0085-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b59/1432504/8d4fe3f159e8/gut00377-0085-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b59/1432504/a63135046334/gut00377-0083-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b59/1432504/3ab71edfee68/gut00377-0083-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b59/1432504/43feb8ac1e79/gut00377-0084-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b59/1432504/3fe060cc931f/gut00377-0085-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b59/1432504/8d4fe3f159e8/gut00377-0085-b.jpg

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本文引用的文献

1
Reliability of the acetylcholinesterase (ACE) reaction in rectal mucosal biopsies for the diagnosis of Hirschsprung's disease.直肠黏膜活检中乙酰胆碱酯酶（ACE）反应对先天性巨结肠症诊断的可靠性。
Z Kinderchir. 1981 Sep;34(1):36-42. doi: 10.1055/s-2008-1063295.
2
The validity of rectal biopsy in relation to morphology and distribution of ganglion cells.直肠活检在神经节细胞形态学和分布方面的有效性。
J Pediatr Surg. 1981 Aug;16(4):433-7. doi: 10.1016/s0022-3468(81)80001-2.
3
'Not Hirschsprung's disease'--rare conditions with some similarities.
Rectal suction biopsy for the diagnosis of Hirschsprung's disease: a systematic review of diagnostic accuracy and complications.
直肠吸引活检诊断先天性巨结肠病：诊断准确性和并发症的系统评价
Pediatr Surg Int. 2015 Sep;31(9):821-30. doi: 10.1007/s00383-015-3742-8. Epub 2015 Jul 9.
4
Histochemical staining for intestinal dysganglionosis: over 30 years experience with more than 1,500 biopsies.肠道神经节发育异常的组织化学染色：超过30年1500多例活检经验
Pediatr Surg Int. 2011 May;27(5):479-86. doi: 10.1007/s00383-010-2849-1.
5
Histochemical staining of rectal suction biopsies as the first investigation in patients with chronic constipation.直肠吸引活检的组织化学染色作为慢性便秘患者的首次检查。
Pediatr Surg Int. 2008 Jul;24(7):785-92. doi: 10.1007/s00383-008-2173-1. Epub 2008 May 8.
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Acetylcholinesterase in Hirschsprung's disease.先天性巨结肠症中的乙酰胆碱酯酶
Pediatr Surg Int. 2005 Apr;21(4):255-63. doi: 10.1007/s00383-005-1383-z. Epub 2005 Mar 10.
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Hirschsprung's disease--a review.先天性巨结肠症——综述
Int J Colorectal Dis. 1991 Feb;6(1):52-62. doi: 10.1007/BF00703963.
S Afr J Surg. 1982 Jun;20(2):97-104.
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Total colonic aganglionosis. Analysis of 16 cases.全结肠无神经节症。16例分析。
Am J Surg. 1982 Jan;143(1):160-8. doi: 10.1016/0002-9610(82)90148-9.
5
Myenteric plexus of the hind-gut: developmental abnormalities in humans and experimental studies.
Ciba Found Symp. 1981;83:326-54. doi: 10.1002/9780470720653.ch16.
6
Acetylthiocholinesterase staining activity of rectal mucosa. Its use in the diagnosis of Hirschsprung's disease.直肠黏膜的乙酰硫代胆碱酯酶染色活性。其在先天性巨结肠症诊断中的应用。
Arch Pathol Lab Med. 1982 Dec;106(13):670-2.
7
Histochemical diagnosis of Hirschsprung disease.先天性巨结肠的组织化学诊断。
Pediatrics. 1982 Jun;69(6):755-61.
8
A clinical evaluation of anorectal pressure studies in the diagnosis of Hirschsprung's disease.肛门直肠压力研究在先天性巨结肠症诊断中的临床评估
Gut. 1972 Feb;13(2):138-46. doi: 10.1136/gut.13.2.138.
9
Acetylcholinesterase activity in suction biopsies of the rectum in the diagnosis of Hirschsprung's disease.直肠吸引活检中乙酰胆碱酯酶活性在先天性巨结肠症诊断中的应用
J Pediatr Surg. 1972 Feb;7(1):11-7. doi: 10.1016/0022-3468(72)90394-6.
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Intensity and proximal extension of acetylcholinesterase activity in the mucosa of the rectosigmoid in Hirschsprung's disease.
J Pediatr Surg. 1973 Jun;8(3):361-8. doi: 10.1016/0022-3468(73)90103-6.