Athow A C, Filipe M I, Drake D P
Department of Paediatric Surgery, United Medical School, Guy's Hospital, London, England.
J Pediatr Surg. 1990 May;25(5):520-6. doi: 10.1016/0022-3468(90)90564-p.
One hundred fifty-seven children, aged 2 days to 15 years, had rectal biopsies for suspected Hirschsprung's disease from 1980 to 1987. Sixty had adequate suction rectal biopsies stained for acetylcholinesterase (ACE); 41 of these were reported as normal and eight showed atypical innervation in children who progressed satisfactorily without surgery. Two showed hyperganglionosis and nine were from children with Hirschsprung's disease. Four of the latter nine biopsies (44%) gave false-negative results in infants aged 9, 10, 13 days, and 6 weeks. The last had total colonic aganglionosis. There were two false-positive results, one in a normal child with atypical innervation and the other in a child with hyperganglionosis. Thus, six of 60 (10%) of ACE-stained suction rectal biopsies gave misleading results.
1980年至1987年间，157名年龄在2天至15岁的儿童因疑似先天性巨结肠接受了直肠活检。60名儿童进行了足够的乙酰胆碱酯酶（ACE）染色吸引直肠活检；其中41例报告为正常，8例在未接受手术且病情进展良好的儿童中显示出非典型神经支配。2例显示神经节增生，9例来自先天性巨结肠患儿。后9例活检中有4例（44%）在9天、10天、13天和6周龄的婴儿中给出了假阴性结果。最后一例患有全结肠无神经节症。有2例假阳性结果，一例在具有非典型神经支配的正常儿童中，另一例在患有神经节增生的儿童中。因此，60例ACE染色吸引直肠活检中有6例（10%）给出了误导性结果。
