Zhang Zhengguang, Wu Haitao, Li Min, Zhou Fuqiong, Huang Yan
Central Laboratory, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Jiangsu, Nanjing, China; School of Medicine, Nanjing University of Chinese Medicine, Jiangsu, Nanjing, China.
School of Medicine, Nanjing University of Chinese Medicine, Jiangsu, Nanjing, China.
Biochim Biophys Acta Rev Cancer. 2025 Feb;1880(1):189263. doi: 10.1016/j.bbcan.2025.189263. Epub 2025 Jan 10.
In recent years, with the deepening understanding of the biological mechanisms underlying tumorigenesis, metabolic reprogramming has emerged as a pivotal process in cancer initiation, progression, and treatment resistance, gradually paving the way for new avenues in precision oncology. Natural herbal ingredients, characterized by their multi-target engagement, low toxicity, and wide-ranging biological activities, exhibit unique advantages in anti-cancer therapy. Nonetheless, the clinical application of these components has been constrained by issues such as poor solubility, low bioavailability, and inadequate stability when administered through traditional delivery methods. The advent of multifunctional nanoformulations has offered solutions to these challenges, substantially advancing the utilization of natural herbal components in precision therapy targeting tumor metabolic reprogramming. This article provides a comprehensive review of the multidimensional features of cancer metabolic reprogramming and its intricate regulatory network, highlighting the latest advancements in metabolic regulation, targeted delivery, and precision therapy achieved through natural herbs and their multifunctional nanomedicines. It also offers insights into future directions in this field. We are justified in believing that continued breakthroughs in this area will usher in safer and more effective treatment options for cancer patients, heralding a new chapter in cancer therapy.
近年来，随着对肿瘤发生生物学机制的深入理解，代谢重编程已成为癌症起始、进展和治疗耐药中的关键过程，逐渐为精准肿瘤学的新途径铺平了道路。天然草药成分具有多靶点作用、低毒性和广泛生物活性的特点，在抗癌治疗中展现出独特优势。然而，这些成分通过传统给药方式应用时，其临床应用受到溶解度差、生物利用度低和稳定性不足等问题的限制。多功能纳米制剂的出现为这些挑战提供了解决方案，极大地推动了天然草药成分在靶向肿瘤代谢重编程精准治疗中的应用。本文全面综述了癌症代谢重编程的多维特征及其复杂的调控网络，突出了通过天然草药及其多功能纳米药物在代谢调控、靶向递送和精准治疗方面取得的最新进展。同时还探讨了该领域的未来方向。我们有理由相信，这一领域的持续突破将为癌症患者带来更安全、更有效的治疗选择，开创癌症治疗的新篇章。
