小鼠全身性沙眼衣原体感染：性病性淋巴肉芽肿生物变种与沙眼生物变种的比较
Systemic Chlamydia trachomatis infection in mice: a comparison of lymphogranuloma venereum and trachoma biovars.
作者信息
Brunham R C, Kuo C, Chen W J
出版信息
Infect Immun. 1985 Apr;48(1):78-82. doi: 10.1128/iai.48.1.78-82.1985.
Abstract
We developed a murine model of systemic infection with Chlamydia trachomatis biovar lymphogranuloma venereum (LGV). The pathological features of this infection resemble those of human LGV infection since both are characterized by granuloma formation. Mice developed resistance to reinfection with LGV, and this resistance was based on cellular immune mechanisms since it was transferable with immune spleen cells but not with immune serum. Resistance required viable organisms for induction. We compared LGV biovar infection with trachoma biovar infection. Trachoma biovar produced similar but less marked microbiological and pathological features. Cross-immunity was less apparent between serovars from trachoma and LGV biovars than it was between serovars within the same biovar. This model of systemic C. trachomatis infection will be useful in exploring virulence features of LGV.
摘要
我们构建了沙眼衣原体性病淋巴肉芽肿生物变种（LGV）全身感染的小鼠模型。这种感染的病理特征与人类LGV感染相似，因为两者均以肉芽肿形成为特征。小鼠对LGV再感染产生了抵抗力，且这种抵抗力基于细胞免疫机制，因为它可通过免疫脾细胞而非免疫血清进行转移。抵抗力的诱导需要活的病原体。我们比较了LGV生物变种感染与沙眼生物变种感染。沙眼生物变种产生了相似但不太明显的微生物学和病理学特征。沙眼生物变种和LGV生物变种血清型之间的交叉免疫比同一生物变种内血清型之间的交叉免疫不太明显。这种沙眼衣原体全身感染模型将有助于探索LGV的毒力特征。
相似文献
1
Systemic Chlamydia trachomatis infection in mice: a comparison of lymphogranuloma venereum and trachoma biovars.小鼠全身性沙眼衣原体感染：性病性淋巴肉芽肿生物变种与沙眼生物变种的比较
Infect Immun. 1985 Apr;48(1):78-82. doi: 10.1128/iai.48.1.78-82.1985.
2
Differences in susceptibilities of the lymphogranuloma venereum and trachoma biovars of Chlamydia trachomatis to neutralization by immune sera.沙眼衣原体性病淋巴肉芽肿生物变种和沙眼生物变种对免疫血清中和作用的敏感性差异。
Infect Immun. 1990 Apr;58(4):938-43. doi: 10.1128/iai.58.4.938-943.1990.
3
Trachoma and LGV biovars of Chlamydia trachomatis share the same glycosaminoglycan-dependent mechanism for infection of eukaryotic cells.沙眼衣原体的沙眼和淋巴肉芽肿性尿道炎生物变种在感染真核细胞时具有相同的依赖于糖胺聚糖的机制。
Mol Microbiol. 1994 Feb;11(3):501-7. doi: 10.1111/j.1365-2958.1994.tb00331.x.
4
Chlamydia trachomatis glycosaminoglycan-dependent and independent attachment to eukaryotic cells.沙眼衣原体对真核细胞的糖胺聚糖依赖性和非依赖性附着
Microb Pathog. 1997 Jan;22(1):23-30. doi: 10.1006/mpat.1996.0087.
5
Plasmid Negative Regulation of CPAF Expression Is Pgp4 Independent and Restricted to Invasive Biovars.质粒对 CPAF 表达的负调控与 Pgp4 无关，且仅限于侵袭性生物型。
mBio. 2018 Jan 30;9(1):e02164-17. doi: 10.1128/mBio.02164-17.
6
Interaction of Chlamydia trachomatis organisms and HeLa 229 cells.沙眼衣原体与海拉229细胞的相互作用。
Infect Immun. 1976 Apr;13(4):1103-9. doi: 10.1128/iai.13.4.1103-1109.1976.
7
Antigenic specificity of human antibody to chlamydia in trachoma and lymphogranuloma venereum.沙眼和性病性淋巴肉芽肿中人类抗衣原体抗体的抗原特异性
J Gen Microbiol. 1986 Jun;132(6):1599-610. doi: 10.1099/00221287-132-6-1599.
8
Differences in outer membrane proteins of the lymphogranuloma venereum and trachoma biovars of Chlamydia trachomatis.沙眼衣原体性病淋巴肉芽肿生物变种与沙眼生物变种外膜蛋白的差异。
Infect Immun. 1985 Nov;50(2):488-94. doi: 10.1128/iai.50.2.488-494.1985.
9
Differential antimicrobial activity of human mononuclear phagocytes against the human biovars of Chlamydia trachomatis.人单核吞噬细胞对沙眼衣原体人生物变种的抗菌活性差异
J Immunol. 1987 Aug 15;139(4):1297-302.
10
Sequence diversity of the 60-kilodalton protein and of a putative 15-kilodalton protein between the trachoma and lymphogranuloma venereum biovars of Chlamydia trachomatis.沙眼衣原体沙眼生物变种和性病淋巴肉芽肿生物变种之间60千道尔顿蛋白及一种假定的15千道尔顿蛋白的序列多样性。
Infect Immun. 1991 Mar;59(3):1196-201. doi: 10.1128/iai.59.3.1196-1201.1991.
引用本文的文献
1
B cells enhance antigen-specific CD4 T cell priming and prevent bacteria dissemination following Chlamydia muridarum genital tract infection.B 细胞增强了沙眼衣原体生殖道感染后抗原特异性 CD4 T 细胞的初始激活，并阻止了细菌的扩散。
PLoS Pathog. 2013 Oct;9(10):e1003707. doi: 10.1371/journal.ppat.1003707. Epub 2013 Oct 31.
2
T lymphocyte immunity in host defence against Chlamydia trachomatis and its implication for vaccine development.T淋巴细胞免疫在宿主抵御沙眼衣原体中的作用及其对疫苗研发的意义。
Can J Infect Dis. 1998 Mar;9(2):99-108. doi: 10.1155/1998/395297.
3
Monitoring the T cell response to genital tract infection.监测T细胞对生殖道感染的反应。
Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):12069-74. doi: 10.1073/pnas.0603866103. Epub 2006 Jul 31.
4
Immunity to murine chlamydial genital infection.对小鼠衣原体性生殖道感染的免疫
Infect Immun. 2002 Jun;70(6):2741-51. doi: 10.1128/IAI.70.6.2741-2751.2002.
5
Secretion of proinflammatory cytokines by epithelial cells in response to Chlamydia infection suggests a central role for epithelial cells in chlamydial pathogenesis.上皮细胞对衣原体感染作出反应而分泌促炎细胞因子，这表明上皮细胞在衣原体发病机制中起核心作用。
J Clin Invest. 1997 Jan 1;99(1):77-87. doi: 10.1172/JCI119136.
6
Ocular sensitization of mice by live (but not irradiated) Chlamydia trachomatis serovar A.沙眼衣原体A血清型活菌株（而非经辐照的菌株）对小鼠的眼部致敏作用。
Infect Immun. 1986 Oct;54(1):9-12. doi: 10.1128/iai.54.1.9-12.1986.
7
Selective infection of astrocytes by Chlamydia trachomatis in primary mixed neuron-glial cell cultures.沙眼衣原体在原代混合神经元-神经胶质细胞培养物中对星形胶质细胞的选择性感染。
Infect Immun. 1986 Dec;54(3):913-6. doi: 10.1128/iai.54.3.913-916.1986.
8
Immune responses of mice after conjunctival exposure to Chlamydia trachomatis serovar A.结膜暴露于沙眼衣原体A血清型后小鼠的免疫反应。
Med Microbiol Immunol. 1988;177(6):349-56. doi: 10.1007/BF02389907.
9
Recombinant murine gamma interferon inhibits Chlamydia trachomatis serovar L1 in vivo.重组鼠γ干扰素在体内抑制沙眼衣原体L1血清型。
Infect Immun. 1988 Jan;56(1):283-6. doi: 10.1128/iai.56.1.283-286.1988.
10
Cytotoxic and immunoregulatory function of intestinal lymphocytes in Chlamydia trachomatis proctitis of nonhuman primates.非人灵长类动物沙眼衣原体直肠炎中肠道淋巴细胞的细胞毒性和免疫调节功能
Infect Immun. 1987 May;55(5):1137-43. doi: 10.1128/iai.55.5.1137-1143.1987.
本文引用的文献
1
Effect of Interferon and Interferon Inducers on Infections with a Nonviral Intracellular Microorganism, Chlamydia trachomatis.干扰素和干扰素诱导剂对非病毒细胞内微生物沙眼衣原体感染的影响。
Infect Immun. 1971 Jun;3(6):825-32. doi: 10.1128/iai.3.6.825-832.1971.
2
Deoxyribonucleic Acid Heterogeneity Between Human and Murine Strains of Chlamydia trachomatis.沙眼衣原体人源和鼠源株间的脱氧核糖核酸异质性。
Infect Immun. 1970 Jul;2(1):24-8. doi: 10.1128/iai.2.1.24-28.1970.
3
One-step growth curves for inclusion blennorrhoea virus in heLa cell monolayers.包涵体性脓溢病毒在HeLa细胞单层中的一步生长曲线。
J Gen Microbiol. 1962 Feb;27:299-304. doi: 10.1099/00221287-27-2-299.
4
A mouse model of Chlamydia trachomatis pneumonitis.沙眼衣原体肺炎的小鼠模型
J Infect Dis. 1980 Feb;141(2):198-202. doi: 10.1093/infdis/141.2.198.
5
Pneumonia due to Chlamydia trachomatis in the immunocompromised (nude) mouse.免疫功能低下（裸）小鼠的沙眼衣原体肺炎
J Infect Dis. 1981 Feb;143(2):238-41. doi: 10.1093/infdis/143.2.238.
6
Chlamydia trachomatis infection in a patient with meningoencephalitis.一名患有脑膜脑炎的患者感染沙眼衣原体。
N Engl J Med. 1981 Apr 9;304(15):910-1. doi: 10.1056/NEJM198104093041514.
7
Serologic evidence for Chlamydia trachomatis myocarditis.沙眼衣原体心肌炎的血清学证据。
Pediatrics. 1982 Jul;70(1):54-6.
8
Lymphokine-mediated microbistatic mechanisms restrict Chlamydia psittaci growth in macrophages.淋巴因子介导的微生物抑制机制限制了鹦鹉热衣原体在巨噬细胞中的生长。
J Immunol. 1982 Jan;128(1):469-74.
9
Interferon gamma blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cells to degrade tryptophan.γ干扰素通过诱导宿主细胞降解色氨酸来阻断弓形虫在人成纤维细胞中的生长。
Proc Natl Acad Sci U S A. 1984 Feb;81(3):908-12. doi: 10.1073/pnas.81.3.908.
10
Inhibition of the growth of Rickettsia prowazekii in cultured fibroblasts by lymphokines.淋巴因子对培养的成纤维细胞中普氏立克次体生长的抑制作用。
J Exp Med. 1983 Mar 1;157(3):974-86. doi: 10.1084/jem.157.3.974.
Zotero 插件