Bénit Paule, Goncalves Judith, El Khoury Riyad, Rak Malgorzata, Favier Judith, Gimenez-Roqueplo Anne-Paule, Rustin Pierre
NeuroDiderot, Inserm, Université Paris Cité, F-75019 Paris, France.
Paris Centre de Recherche Cardiovasculaire (PARCC), Inserm, Université Paris Cité, F-75015 Paris, France.
Biomedicines. 2022 Jul 25;10(8):1788. doi: 10.3390/biomedicines10081788.
Research focused on succinate dehydrogenase (SDH) and its substrate, succinate, culminated in the 1950s accompanying the rapid development of research dedicated to bioenergetics and intermediary metabolism. This allowed researchers to uncover the implication of SDH in both the mitochondrial respiratory chain and the Krebs cycle. Nowadays, this theme is experiencing a real revival following the discovery of the role of SDH and succinate in a subset of tumors and cancers in humans. The aim of this review is to enlighten the many questions yet unanswered, ranging from fundamental to clinically oriented aspects, up to the danger of the current use of SDH as a target for a subclass of pesticides.
20世纪50年代，随着生物能量学和中间代谢研究的迅速发展，对琥珀酸脱氢酶（SDH）及其底物琥珀酸的研究达到了顶峰。这使研究人员得以揭示SDH在线粒体呼吸链和三羧酸循环中的作用。如今，随着SDH和琥珀酸在人类部分肿瘤和癌症中的作用被发现，这一主题正经历着真正的复兴。本综述的目的是阐明许多尚未得到解答的问题，从基础方面到临床导向方面，直至目前将SDH用作一类杀虫剂靶点的风险。
