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造血细胞移植（HCT）后低丙种球蛋白血症相关复发性菌血症的缓解

Resolution of hypogammaglobulinemia-associated recurrent bacteraemia after hematopoietic cell transplantation (HCT).

作者信息

Karofylakis Emmanouil, Gkrania-Klotsas Effrossyni, Uttenthal Benjamin, Kumararatne Dinakantha

机构信息

Department of Infectious Diseases, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.

Department of Haematology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.

出版信息

J Allergy Clin Immunol Glob. 2024 Nov 26;4(1):100378. doi: 10.1016/j.jacig.2024.100378. eCollection 2025 Feb.

DOI:10.1016/j.jacig.2024.100378
PMID:39802398
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11719299/
Abstract

Primary or secondary hypogammaglobulinemia is associated with persistent norovirus and infections despite immunoglobulin replacement therapy. Allogeneic hematopoietic cell transplantation for hematologic indications can lead to immune reconstitution by correcting a previously undiagnosed concurrent primary immunodeficiency.

摘要

原发性或继发性低丙种球蛋白血症与持续的诺如病毒感染以及尽管进行了免疫球蛋白替代治疗仍存在感染相关。用于血液学适应症的异基因造血细胞移植可通过纠正先前未诊断出的并发原发性免疫缺陷来实现免疫重建。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e7d/11719299/d67d90efe50b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e7d/11719299/d67d90efe50b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e7d/11719299/d67d90efe50b/gr1.jpg

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本文引用的文献

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J Allergy Clin Immunol Pract. 2023 Nov;11(11):3493-3501.e4. doi: 10.1016/j.jaip.2023.06.050. Epub 2023 Jul 3.
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Chronic or recurrent Campylobacter enteritis in primary immunodeficiency: A UK national case-series and review of the literature.原发性免疫缺陷中的慢性或复发性弯曲杆菌肠炎：一项英国全国性病例系列研究及文献综述
J Allergy Clin Immunol Pract. 2023 Sep;11(9):2948-2954.e4. doi: 10.1016/j.jaip.2023.05.046. Epub 2023 Jun 8.
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利妥昔单抗治疗后低丙种球蛋白血症、迟发性中性粒细胞减少和感染。
Ann Allergy Asthma Immunol. 2023 Jun;130(6):699-712. doi: 10.1016/j.anai.2023.01.018. Epub 2023 Jan 24.
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Secondary Immune Deficiency and Primary Immune Deficiency Crossovers: Hematological Malignancies and Autoimmune Diseases.继发性免疫缺陷和原发性免疫缺陷的交叉：血液系统恶性肿瘤和自身免疫性疾病。
Front Immunol. 2022 Jul 18;13:928062. doi: 10.3389/fimmu.2022.928062. eCollection 2022.
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Practical guidance for the diagnosis and management of secondary hypogammaglobulinemia: A Work Group Report of the AAAAI Primary Immunodeficiency and Altered Immune Response Committees.继发性低丙种球蛋白血症的诊断和管理实用指南：美国过敏、哮喘和免疫学学会原发性免疫缺陷和免疫反应改变工作组的报告。
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