Martin Anne C, Sadler Jacob M, Simkin Alfred, Musonda Michael, Katowa Ben, Matoba Japhet, Schue Jessica, Simulundu Edgar, Bailey Jeffrey A, Moss William J, Juliano Jonathan J, Fola Abebe A
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore USA.
Department of Epidemiology, University of North Carolina, Chapel-Hill USA.
medRxiv. 2025 Jan 2:2025.01.02.24319706. doi: 10.1101/2025.01.02.24319706.
Increasing artemisinin partial resistance (ArtR) due to mutations in the gene encoding Kelch13 () protein in eastern Africa is of urgent concern, and mutations, such as P441L, continue to emerge. We used an amplicon deep-sequencing panel to estimate the prevalence of ArtR mutations in samples collected between 2018 and 2023 in southern Zambia. P441L was present in 30 of 501 samples (6%), and prevalence increased over time (0% to 7.2%). Further studies of the P441L mutation are needed to document its geographical origin, distribution and impact on treatment outcomes.
由于东非编码Kelch13（）蛋白的基因突变导致青蒿素部分抗性（ArtR）增加，这一情况令人迫切担忧，而且诸如P441L等突变仍在不断出现。我们使用扩增子深度测序平台来估计2018年至2023年期间在赞比亚南部采集的样本中ArtR突变的流行情况。在501个样本中的30个（6%）样本中发现了P441L突变，且其流行率随时间增加（从0%增至7.2%）。需要对P441L突变进行进一步研究，以记录其地理起源、分布及其对治疗结果的影响。
