Ewain Najla S, Alshehri Sameerah, Aladwani Majed M
Department of Medicine, Division of Endocrinology and Metabolism, King Abdulaziz Medical City, Riyadh, SAU.
Department of Medicine, King Abdullah International Medical Research Center, Riyadh, SAU.
Cureus. 2024 Dec 10;16(12):e75495. doi: 10.7759/cureus.75495. eCollection 2024 Dec.
Epithelioid hemangioendothelioma (EHE) is a rare form of vascular neoplasm that can manifest with various symptoms or be discovered incidentally in asymptomatic patients. In this report, we describe a case of a 56-year-old male who presented with progressive lower limb weakness over four years. The evaluation revealed severe hypophosphatemia, an inappropriately normal fibroblast growth factor 23 C-terminal (cFGF-23) level, and a 30 x 20 mm hypermetabolic right pleural mass, which was subsequently proven to be EHE. Following tumor resection, the patient experienced complete recovery, with normalization of his serum phosphate levels and resolution of his presenting symptoms. This case highlights the association between EHE and oncogenic osteomalacia, a rare paraneoplastic syndrome.
上皮样血管内皮瘤（EHE）是一种罕见的血管肿瘤形式，可表现为各种症状，或在无症状患者中偶然发现。在本报告中，我们描述了一例56岁男性患者，其在四年内出现进行性下肢无力。评估发现严重低磷血症、成纤维细胞生长因子23 C末端（cFGF - 23）水平异常正常，以及一个30×20mm的右胸膜高代谢肿块，随后被证实为EHE。肿瘤切除后，患者完全康复，血清磷酸盐水平恢复正常，症状消失。该病例突出了EHE与致癌性骨软化症（一种罕见的副肿瘤综合征）之间的关联。
