Zak O, Tosch W, Sande M A
J Antimicrob Chemother. 1985 Jan;15 Suppl A:273-82. doi: 10.1093/jac/15.suppl_a.273.
Laboratory tests of antibiotic activity in vitro, ranging from simple MIC determinations to sophisticated, computerized models for studying the effects of simulated plasma concentration-time curves of antibiotics in broth, differ inherently from tests in vivo in both the general and specific variables. There are therefore likely to be discrepancies between the results obtained. Apart from the obvious lack of host-defence mechanisms in the in-vitro tests systems, the reasons for these discrepancies have still not been fully elucidated. For the time being, it seems unrealistic to expect that in-vitro tests could be developed that would make it possible to predict the efficacy of any antibiotic against any specific infection in vivo.
抗生素体外活性的实验室检测，从简单的最低抑菌浓度（MIC）测定到用于研究肉汤中抗生素模拟血浆浓度 - 时间曲线影响的复杂计算机模型，在一般变量和特定变量方面都与体内试验存在本质差异。因此，所获得的结果之间可能存在差异。除了体外测试系统明显缺乏宿主防御机制外，这些差异的原因仍未完全阐明。目前，期望开发出能够预测任何抗生素对体内任何特定感染疗效的体外测试似乎是不现实的。
