一例因使用阿托伐醌导致的角膜混浊病例。
A case of corneal opacity caused by atovaquone administration.
作者信息
Ashizuka Takeyoshi, Uematsu Masafumi, Mohamed Mohamed Talaat, Kusano Mao, Helmy Mohamed Yasser, Inoue Daisuke, Kitaoka Takashi
机构信息
Department of Ophthalmology and Visual Sciences, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki City, Nagasaki, 852-8501, Japan.
出版信息
Am J Ophthalmol Case Rep. 2024 Dec 12;37:102235. doi: 10.1016/j.ajoc.2024.102235. eCollection 2025 Mar.
PURPOSE
Atovaquone is an alternative drug that is used for the prevention and treatment of pneumonia when the first-line drug, sulfamethoxazole-trimethoprim (ST combination), cannot be used due to side effects. However, atovaquone is known to cause ocular side effects including oculomucocutaneous syndrome and vortex keratopathy. In this report, we describe a patient who developed bilateral white granular diffuse corneal opacity that extended from the corneal sub-epithelium to the stroma after continuous oral atovaquone administration for 14 months.
OBSERVATIONS
The patient was a 15-year-old male with no prior ophthalmological or family medical history, but with a medical history of aplastic anemia treatment at our hospital's pediatric department. Examination showed bilateral diffuse white granular corneal opacity that extended from the sub-epithelium to the stroma, with no other abnormalities in the anterior and posterior segments of both eyes.
CONCLUSIONS AND IMPORTANCE
We encountered a rare case of bilateral corneal opacity resulting from oral atovaquone administration. Regular long-term ophthalmological examinations are necessary for patients taking atovaquone.
目的
阿托伐醌是一种替代药物，当一线药物磺胺甲恶唑 - 甲氧苄啶（ST合剂）因副作用无法使用时，用于预防和治疗肺炎。然而，已知阿托伐醌会引起眼部副作用，包括眼黏膜皮肤综合征和涡状角膜病变。在本报告中，我们描述了一名患者，在连续口服阿托伐醌14个月后，出现双侧白色颗粒状弥漫性角膜混浊，从角膜上皮下延伸至基质层。
观察结果
该患者为15岁男性，既往无眼科或家族病史，但有在我院儿科接受再生障碍性贫血治疗的病史。检查显示双侧弥漫性白色颗粒状角膜混浊，从上皮下延伸至基质层，双眼前后节无其他异常。
结论与意义
我们遇到了一例因口服阿托伐醌导致双侧角膜混浊的罕见病例。服用阿托伐醌的患者需要定期进行长期眼科检查。
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