Zhou Shushu, Liu Zhenhua, Peng Xueyu, Zhang Dailiang, Yang Minghui
Hunan Provincial Key Laboratory of Micro & Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, China.
Sansure Biotech Inc, Changsha, 410205, China.
Mikrochim Acta. 2025 Jan 13;192(2):69. doi: 10.1007/s00604-024-06942-9.
An exciting upconversion nanoprobe conditioning strategy is proposed to improve the signal-to-background ratio (SBR) through a dye-sensitized strategy, in which the dye functions both as a recognition unit of the detection target and as a sensitizer to amplify the visible luminescence of the lanthanide-doped upconversion nanoparticles (UCNPs), instead of a quencher. The application of this dye-sensitized upconversion nanoprobe to the visual detection of nerve agent mimics diethoxy phosphatidylcholine (DCP) showed excellent detection performance, with up to 110-fold enhancement of the luminescence response of the probe in DCP solution and a detection limit as low as 2 nM. Finally, we performed visual detection of DCP solution and vapor by using test strips containing the probe. It is promising to apply the probe to monitor the leakage of DCP in the real environment.
提出了一种令人兴奋的上转换纳米探针调节策略，通过染料敏化策略提高信号背景比（SBR），其中染料既作为检测目标的识别单元，又作为敏化剂来放大镧系掺杂上转换纳米颗粒（UCNP）的可见发光，而不是淬灭剂。这种染料敏化上转换纳米探针在神经毒剂模拟物二乙氧基磷脂酰胆碱（DCP）的视觉检测中的应用显示出优异的检测性能，在DCP溶液中探针的发光响应增强高达110倍，检测限低至2 nM。最后，我们使用含有该探针的试纸对DCP溶液和蒸气进行了视觉检测。将该探针应用于监测实际环境中DCP的泄漏具有广阔前景。
