Zeng Lintao, Chen Tianhong, Zhu Beitong, Koo Seyoung, Tang Yonghe, Lin Weiying, James Tony D, Kim Jong Seung
School of Light Industry and Food Engineering, Guangxi University Nanning 530004 China.
College of Chemistry, Beijing Normal University Beijing 100875 China.
Chem Sci. 2022 Mar 23;13(16):4523-4532. doi: 10.1039/d2sc00299j. eCollection 2022 Apr 20.
Chemical warfare agents (CWAs) such as phosgene and nerve agents pose serious threats to our lives and public security, but no tools can simultaneously screen multiple CWAs in seconds. Here, we rationally designed a robust sensing platform based on 8-cyclohexanyldiamino-BODIPY (BODIPY-DCH) to monitor diverse CWAs in different emission channels. -cyclohexanyldiamine as the reactive site provides optimal geometry and high reactivity, allowing -BODIPY-DCH to detect CWAs with a quick response and high sensitivity, while -BODIPY-DCH has much weaker reactivity to CWAs due to intramolecular H-bonding. Upon reaction with phosgene, -BODIPY-DCH was rapidly converted to imidazolone BODIPY (<3 s), triggering green fluorescence with good sensitivity (LOD = 0.52 nM). -BODIPY-DCH coupled with nerve agent mimics, affording a blue fluorescent 8-amino-BODIPY tautomer. Furthermore, a portable test kit using -BODIPY-DCH displayed an instant response and low detection limits for multiple CWAs. This platform enables rapid and highly sensitive visual screening of various CWAs.
诸如光气和神经毒剂等化学战剂对我们的生命和公共安全构成严重威胁，但目前还没有工具能够在数秒内同时筛查多种化学战剂。在此，我们合理设计了一种基于8-环己基二氨基-BODIPY（BODIPY-DCH）的强大传感平台，以在不同发射通道中监测多种化学战剂。环己二胺作为反应位点提供了最佳的几何结构和高反应活性，使得-BODIPY-DCH能够快速响应并高灵敏度地检测化学战剂，而-BODIPY-DCH由于分子内氢键作用，对化学战剂的反应活性要弱得多。与光气反应时，-BODIPY-DCH迅速转化为咪唑酮BODIPY（<3秒），触发具有良好灵敏度的绿色荧光（检测限 = 0.52 nM）。-BODIPY-DCH与神经毒剂模拟物结合，生成蓝色荧光的8-氨基-BODIPY互变异构体。此外，使用-BODIPY-DCH的便携式检测试剂盒对多种化学战剂显示出即时响应和低检测限。该平台能够对各种化学战剂进行快速且高灵敏度的视觉筛查。
