Gelormini Francesco, Ricardi Federico, Parisi Guglielmo, Vallino Veronica, Ghezzo Beatrice, Cucciarelli Claudia, Marolo Paola, Cicinelli Maria Vittoria, Govetto Andrea, Romano Mario R, Borrelli Enrico, Reibaldi Michele
Department of Surgical Sciences, Eye Clinic Section, University of Turin, Turin, Italy.
School of Medicine, Vita-Salute San Raffaele University, Department of Ophthalmology, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Invest Ophthalmol Vis Sci. 2025 Jan 2;66(1):31. doi: 10.1167/iovs.66.1.31.
This study aimed to comprehensively assess visual performance in eyes with idiopathic epiretinal membrane (iERM). Additionally, it sought to explore the associations between optical coherence tomography (OCT) imaging biomarkers and visual performance in patients with iERM.
In this prospective, non-interventional study, 57 participants with treatment-naïve iERM from the University of Turin, between September 2023 and March 2024 were enrolled. Visual performance was measured using distance best-corrected visual acuity (BCVA), near BCVA, and maximum reading speed (MaxRS). Structural retinal imaging biomarkers were obtained from OCT, focusing on retinal layer thicknesses and epiretinal membrane characteristics. Statistical analyses, including linear regression and multivariate analysis, were used to determine relationships between visual function and imaging metrics.
Monocular distance BCVA (0.37 ± 0.23 LogMAR), near BCVA (0.59 ± 0.18 LogMAR), and MaxRS (108.88 [68.38] words per minute [wpm]) in patients with iERM were significantly reduced compared with reference values. Both near BCVA and reading speed exhibited a greater percentage reduction than distance visual acuity. Patients with phakic showed worse visual acuity than patients with pseudophakia, although their reading performance was similar. Higher outer plexiform layers thickness and inner retinal thickness were associated with decreased distance and near visual acuity and reduced reading speed (beta, P value).
The iERM predominantly impacts near visual performance, with near visual acuity and reading speed being more affected than distance visual acuity. Structural OCT biomarkers, particularly retinal thickness in specific regions, correlate with worse functional impairments. This highlights the importance of near vision assessments and imaging biomarkers for a comprehensive evaluation of visual impairment in iERM.
本研究旨在全面评估特发性视网膜前膜（iERM）患者的视觉功能。此外，还试图探讨光学相干断层扫描（OCT）成像生物标志物与iERM患者视觉功能之间的关联。
在这项前瞻性、非干预性研究中，招募了2023年9月至2024年3月期间来自都灵大学的57例未经治疗的iERM患者。使用远距离最佳矫正视力（BCVA）、近距离BCVA和最大阅读速度（MaxRS）来测量视觉功能。从OCT获得视网膜结构成像生物标志物，重点关注视网膜层厚度和视网膜前膜特征。采用线性回归和多变量分析等统计分析方法来确定视觉功能与成像指标之间的关系。
与参考值相比，iERM患者的单眼远距离BCVA（0.37±0.23 LogMAR）、近距离BCVA（0.59±0.18 LogMAR）和MaxRS（108.88[68.38]字/分钟[wpm]）显著降低。近距离BCVA和阅读速度的降低百分比均高于远距离视力。有晶状体眼患者的视力比无晶状体眼患者差，尽管他们的阅读表现相似。较高的外丛状层厚度和视网膜内层厚度与远距离和近距离视力下降以及阅读速度降低相关（β，P值）。
iERM主要影响近距离视觉功能，近距离视力和阅读速度比远距离视力受影响更大。OCT结构生物标志物，特别是特定区域的视网膜厚度，与更严重的功能损害相关。这突出了近距离视力评估和成像生物标志物对全面评估iERM患者视力损害的重要性。
