Nagel Ines D, Heinke Anna, Agnihotri Akshay P, Yassin Shaden, Cheng Lingyun, Camp Andrew S, Scott Nathan L, Kalaw Fritz Gerald P, Borooah Shyamanga, Bartsch Dirk-Uwe G, Mueller Arthur J, Mehta Nehal, Freeman William R
Jacobs Retina Center, Shiley Eye Institute, University of California San Diego, La Jolla, CA, USA.
Viterbi Family Department of Ophthalmology and Shiley Eye Institute, University of California San Diego, La Jolla, CA, USA.
Transl Vis Sci Technol. 2025 Jan 2;14(1):11. doi: 10.1167/tvst.14.1.11.
To compare the assessment of clinically relevant retinal and choroidal lesions as well as optic nerve pathologies using a novel three-wavelength ultra-widefield (UWF) scanning laser ophthalmoscope with established retinal imaging techniques for ophthalmoscopic imaging.
Eighty eyes with a variety of retinal and choroidal lesions were assessed on the same time point using Topcon color fundus photography (CFP) montage, Optos red/green (RG), Heidelberg SPECTRALIS MultiColor 55-color montage (MCI), and novel Optos red/green/blue (RGB). Paired images of the optic nerve, retinal, or choroidal lesions were initially diagnosed based on CFP imaging. The accuracy of the imaging was then evaluated in comparison to CFP using a grading scale ranging from -1 (losing imaging information) to +1 (gaining imaging information).
Eighty eyes of 43 patients with 116 retinal or choroidal pathologies, as well as 59 eyes with optic nerve imaging using CFP, MCI, RG, and RGB, were included in this study. Across all subgroups, RGB provided significantly more accurate clinical imaging with CFP as ground truth and compared to other modalities. This was true comparing RGB to both RG (P = 0.0225) and MCI (P < 0.001) overall. Although RGB provided more accurate clinical information overall, it was inferior to RG for melanocytic choroidal lesions (P = 0.011).
RGB can be considered as a useful tool to detect characteristics of central, midperipheral, and peripheral retinal lesions. Regarding melanocytic choroidal lesions, RGB was inferior to RG, and MCI was inferior to both RG and RGB modalities due to color changes.
Traditional retinal ultra-widefield imaging uses two wavelengths. Here, we evaluated three wavelengths for ultra-widefield imaging. We examined new optics (basic science) effect on patient imaging (clinical care).
使用新型三波长超广角（UWF）扫描激光检眼镜与用于检眼镜成像的既定视网膜成像技术，比较对临床相关视网膜和脉络膜病变以及视神经病变的评估。
在同一时间点，使用拓普康彩色眼底照相（CFP）蒙片、Optos红/绿（RG）、海德堡SPECTRALIS多色55色蒙片（MCI）和新型Optos红/绿/蓝（RGB）对80只患有各种视网膜和脉络膜病变的眼睛进行评估。视神经、视网膜或脉络膜病变的配对图像最初基于CFP成像进行诊断。然后使用从-1（丢失成像信息）到+1（获得成像信息）的分级量表，与CFP相比评估成像的准确性。
本研究纳入了43例患者的80只眼睛，这些眼睛患有116种视网膜或脉络膜病变，以及59只使用CFP、MCI、RG和RGB进行视神经成像的眼睛。在所有亚组中，以CFP作为金标准并与其他模式相比，RGB提供了明显更准确的临床成像。总体而言，将RGB与RG（P = 0.0225）和MCI（P < 0.001）相比均是如此。尽管RGB总体上提供了更准确的临床信息，但对于黑素细胞性脉络膜病变，其不如RG准确（P = 0.011）。
RGB可被视为检测中央、中周边和周边视网膜病变特征的有用工具。对于黑素细胞性脉络膜病变，RGB不如RG，并且由于颜色变化，MCI不如RG和RGB模式。
传统的视网膜超广角成像使用两个波长。在此，我们评估了用于超广角成像的三个波长。我们研究了新光学（基础科学）对患者成像（临床护理）的影响。
