小儿造血细胞移植长期存活者中克隆性造血增加。
Increased Clonal Hematopoiesis in Long-term Survivors of Pediatric Hematopoietic Cell Transplantation.
作者信息
Müskens Konradin F, Wieringa Nienke, van Bergen Maaike G J M, Bense Joëll E, Te Pas Brigit M, de Pagter Anne P J, Lankester Arjan C, Bierings Marc B, Neuberg Donna S, Haitjema Saskia, Kremer Leontien C M, Huls Gerwin A, Nierkens Stefan, Jansen Joop H, Lindemans Caroline A, de Graaf Aniek O, Belderbos Mirjam E
机构信息
Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.
Laboratory of Hematology, Radboud University Medical Center, Nijmegen, the Netherlands.
出版信息
Blood Cancer Discov. 2025 Mar 4;6(2):110-118. doi: 10.1158/2643-3230.BCD-24-0136.
As survival of HCT recipients continues to improve, late treatment effects gain importance. We demonstrate that pediatric HCT recipients show increased risk of CH compared with age-matched controls. Prospective studies are crucial to understand the clinical implications of posttransplant CH in this young population.
随着造血干细胞移植（HCT）受者的生存率不断提高，晚期治疗效果变得愈发重要。我们证明，与年龄匹配的对照组相比，儿科HCT受者发生脑血管疾病（CH）的风险增加。前瞻性研究对于了解这一年轻人群中移植后CH的临床意义至关重要。
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