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The revolution in pharmacotherapy: from herbs to pills, moulds, antibodies to genetic tools.

作者信息

Lüscher Thomas F

机构信息

Heart Division, Royal Brompton and Harefield Hospitals, GSTT, Sydney Street, London SW3 6NP, UK.

King's College, Strand, London WC2R 2LS, UK.

出版信息

Eur Heart J Cardiovasc Pharmacother. 2025 Mar 13;11(2):109-111. doi: 10.1093/ehjcvp/pvae098.

DOI:10.1093/ehjcvp/pvae098
PMID:39805730
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11905760/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bc9/11905760/054071602af3/pvae098fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bc9/11905760/68cc269290b5/pvae098fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bc9/11905760/054071602af3/pvae098fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bc9/11905760/68cc269290b5/pvae098fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bc9/11905760/054071602af3/pvae098fig2.jpg

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Precise genomic editing of pathogenic mutations in rescues dilated cardiomyopathy.精确的基因组编辑可纠正致病性突变，从而挽救扩张型心肌病。
Sci Transl Med. 2022 Nov 23;14(672):eade1633. doi: 10.1126/scitranslmed.ade1633.
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Efficacy and Safety of an Investigational Single-Course CRISPR Base-Editing Therapy Targeting in Nonhuman Primate and Mouse Models.在非人类灵长类动物和小鼠模型中靶向 的一种新型单疗程 CRISPR 碱基编辑疗法的疗效和安全性。
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Lancet. 2021 May 29;397(10289):2060-2069. doi: 10.1016/S0140-6736(21)00520-1. Epub 2021 May 17.
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