Amin Fatemeh, Basirat Hosein, Parvaz Najmeh, Khademalhosseini Morteza, Hakimizadeh Elham, Fatemi Iman
Physiology-Pharmacology Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Department of Physiology and Pharmacology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
BMC Pulm Med. 2025 Jan 13;25(1):17. doi: 10.1186/s12890-025-03484-5.
Paraquat (PQ) is a widely used pesticide, can cause severe intoxication and respiratory failure. Myrtenol (Mrl), an essential oil derived in various plants, exhibits several biological properties, including anti-inflammatory and antioxidant activities. This study aims to investigate the protective potential of Mrl against oxidative stress and inflammation caused by PQ exposure.
Twenty-five Wistar albino rats were divided into the following groups (n = 5 in each group): a control group (treated by dimethyl sulfoxide (DMSO)), a PQ group (exposed to 54 mg/m³ aerosol PQ), and two treatment groups that were exposed to PQ aerosol and administered oral Mrl at doses of 25 mg/kg/day and 50 mg/kg/day, respectively. The final group was exposed to PQ aerosol and treated with oral dexamethasone at a dose of 0.03 mg/kg/day. Various hematological, oxidative, inflammatory, and pathological indices were measured at the conclusion of the treatment period.
PQ decreases the levels or activities of superoxide dismutase (SOD), catalase (CAT), and Thiol, while increasing the levels or activities of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and malondialdehyde (MDA). Mrl restored activites of SOD, and CAT, as well as thiol levels to near-control values while reducing TNF-α, IL-6, and MDA levels. Pathological studies further confirmed the therapeutic effects of Mrl.
The results of this study demonstrate the promising therapeutic effects of Mrl against inhaled PQ in rats.
百草枯（PQ）是一种广泛使用的杀虫剂，可导致严重中毒和呼吸衰竭。桃金娘烯醇（Mrl）是一种从多种植物中提取的精油，具有多种生物学特性，包括抗炎和抗氧化活性。本研究旨在探讨Mrl对PQ暴露引起的氧化应激和炎症的保护潜力。
将25只Wistar白化大鼠分为以下几组（每组n = 5）：对照组（用二甲基亚砜（DMSO）处理）、PQ组（暴露于54 mg/m³的PQ气雾剂），以及两个分别暴露于PQ气雾剂并口服Mrl，剂量分别为25 mg/kg/天和50 mg/kg/天的治疗组。最后一组暴露于PQ气雾剂并口服地塞米松，剂量为0.03 mg/kg/天。在治疗期结束时测量各种血液学、氧化、炎症和病理指标。
PQ降低了超氧化物歧化酶（SOD）、过氧化氢酶（CAT）和硫醇的水平或活性，同时增加了肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）和丙二醛（MDA）的水平或活性。Mrl将SOD和CAT的活性以及硫醇水平恢复到接近对照值，同时降低了TNF-α、IL-6和MDA水平。病理研究进一步证实了Mrl的治疗效果。
本研究结果表明Mrl对大鼠吸入PQ具有良好的治疗效果。
