Zhang Longxiao, Zhou Yunfei, Yang Zhongbo, Jiang Liangchao, Yan Xinyang, Zhu Wenkai, Shen Yi, Wang Bolong, Li Jiaxi, Song Jinning
Department of Neurosurgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China.
J Neuroinflammation. 2025 Jan 13;22(1):7. doi: 10.1186/s12974-025-03334-5.
Lipid droplets (LDs), serving as the convergence point of energy metabolism and multiple signaling pathways, have garnered increasing attention in recent years. Different cell types within the central nervous system (CNS) can regulate energy metabolism to generate or degrade LDs in response to diverse pathological stimuli. This article provides a comprehensive review on the composition of LDs in CNS, their generation and degradation processes, their interaction mechanisms with mitochondria, the distribution among different cell types, and the roles played by these cells-particularly microglia and astrocytes-in various prevalent neurological disorders. Additionally, we also emphasize the paradoxical role of LDs in post-cerebral ischemia inflammation and explore potential underlying mechanisms, aiming to identify novel therapeutic targets for this disease.
脂滴（LDs）作为能量代谢和多种信号通路的汇聚点，近年来受到了越来越多的关注。中枢神经系统（CNS）内的不同细胞类型可以调节能量代谢，以响应各种病理刺激产生或降解脂滴。本文全面综述了中枢神经系统中脂滴的组成、其产生和降解过程、它们与线粒体的相互作用机制、在不同细胞类型中的分布，以及这些细胞——特别是小胶质细胞和星形胶质细胞——在各种常见神经系统疾病中所起的作用。此外，我们还强调了脂滴在脑缺血后炎症中的矛盾作用，并探讨了潜在的机制，旨在为该疾病确定新的治疗靶点。
