Yousaf Saba, Shehzadi Anum, Ahmad Muhammad, Asrar Ahmad, Ahmed Ishtiaq, Iqbal Hafiz M N, Hussen Bule Mohammed
Department of Biochemistry, Enzyme Biotechnology Laboratory, University of Agriculture Faisalabad.
Department of Biochemistry, Riphah International University, Faisalabad Campus.
Int J Surg. 2024 Dec 1;110(12):8025-8036. doi: 10.1097/JS9.0000000000002117.
Cervical cancer ranks as the fourth most common cancer among women globally, posing a significant mortality risk. Persistent infection with high-risk human papillomavirus (HPV) is the primary instigator of cervical cancer development, often alongside coinfection with other viruses, precipitating various malignancies. This study aimed to explore recent biotechnological advances in understanding HPV infection dynamics, host interactions, and its role in oncogenesis. The gathered data shed light on HPV biology, host-virus interplay, viral coinfections, and cellular transformations leading to HPV-associated cancers. Recent years have seen the introduction of diverse vaccination strategies, including live attenuated, subunit, and DNA-based vaccines, complemented by innovative nanotechnology and plant-based products. Despite rich data addressing research inquiries, urgent calls echo for the implementation of contemporary screening and therapeutic modalities at clinical levels. Moreover, extensive public awareness campaigns are imperative to alleviate the burden of HPV-related diseases, emphasizing the necessity for proactive intervention strategies in combating this global health challenge.
宫颈癌是全球女性中第四大常见癌症，具有重大的死亡风险。高危型人乳头瘤病毒（HPV）的持续感染是宫颈癌发生的主要诱因，通常还伴有与其他病毒的合并感染，从而引发各种恶性肿瘤。本研究旨在探索在理解HPV感染动态、宿主相互作用及其在肿瘤发生中的作用方面的最新生物技术进展。所收集的数据揭示了HPV生物学、宿主-病毒相互作用、病毒合并感染以及导致HPV相关癌症的细胞转化。近年来，已经推出了多种疫苗接种策略，包括减毒活疫苗、亚单位疫苗和基于DNA的疫苗，同时还有创新的纳米技术和植物源产品作为补充。尽管有丰富的数据可用于解答研究问题，但临床上仍迫切需要实施当代筛查和治疗方法。此外，开展广泛的公众宣传活动对于减轻HPV相关疾病的负担至关重要，强调了采取积极干预策略应对这一全球健康挑战的必要性。
