Parkinson C R, Burnett G R, Smith G, Pradhan M, Gallob J, Qaqish J
Haleon, Weybridge, Surrey, UK.
Haleon, Warren, New Jersey, USA.
J Esthet Restor Dent. 2025 Jun;37(6):1483-1493. doi: 10.1111/jerd.13373. Epub 2025 Jan 13.
This study aims to evaluate extrinsic tooth stain removal and whitening efficacy of two experimental dentifrices containing (i) 5% sodium tripolyphosphate (STP)/1% micronized alumina or (ii) 5% STP/1% micronized alumina with abrasive silica (ED2) compared to a regular fluoride dentifrice (RFD) following 8 weeks of use.
This was a single-center, randomized, controlled, blind, three-arm, stratified, parallel-group study. Eligible participants underwent clinical assessment of stain on the facial/lingual surfaces of maxillary and mandibular teeth using the modified Lobene stain index (MLSI), and shade of the facial surfaces of the central and lateral maxillary incisors using the VITA Bleachedguide 3D-Master (VITA) shade guide. Participants brushed twice daily with their assigned dentifrice and returned to the clinic for clinical assessments at weeks 4 and 8.
A total of 272 participants completed the study (281 screened, 279 randomized). Both experimental dentifrices demonstrated statistically significant reduction from baseline and significant differences compared to RFD for MLSI and VITA shade scores at 4 and 8 weeks. 10 treatment-related treatment-emergent adverse events were reported in seven participants. All were resolved at the end of the study.
This study demonstrated that dentifrices containing 5% STP/1% micronized alumina provide enhanced stain removal and shade improvements compared to a regular dentifrice. Study treatments were generally well tolerated.
A low-abrasion daily-use fluoride dentifrice containing 1% micronized alumina and 5% STP, suitable for people at risk of erosive toothwear and/or dentin hypersensitivity, can provide clinically meaningful superior reductions in tooth stain, which translates into a visibly noticeable improvement in tooth shade.
本研究旨在评估两种实验性牙膏的外源性牙齿污渍清除和美白效果，这两种牙膏分别含有（i）5%三聚磷酸钠（STP）/1%微粉化氧化铝，或（ii）5% STP/1%微粉化氧化铝与磨料二氧化硅（ED2），与常规含氟牙膏（RFD）相比，使用8周后的效果。
这是一项单中心、随机、对照、双盲、三臂、分层、平行组研究。符合条件的参与者使用改良的洛贝内污渍指数（MLSI）对上下颌牙齿的唇/舌面污渍进行临床评估，并使用VITA Bleachedguide 3D-Master（VITA）比色板对上颌中切牙和侧切牙唇面的颜色进行评估。参与者每天用分配的牙膏刷牙两次，并在第4周和第8周返回诊所进行临床评估。
共有272名参与者完成了研究（281名筛查，279名随机分组）。两种实验性牙膏在第4周和第8周时，与RFD相比，MLSI和VITA颜色评分均显示出与基线相比有统计学意义的降低以及显著差异。7名参与者报告了10起与治疗相关的治疗中出现的不良事件。所有事件在研究结束时均得到解决。
本研究表明，与常规牙膏相比，含有5% STP/1%微粉化氧化铝的牙膏能更好地去除污渍并改善牙齿颜色。研究治疗方法总体耐受性良好。
一种低磨损的日用含氟牙膏，含有1%微粉化氧化铝和5% STP，适用于有牙齿磨损和/或牙本质过敏风险的人群，可在临床上显著减少牙齿污渍，从而使牙齿颜色有明显可见的改善。
