Zhang Peng, Yang Jing, Zhou Qing, Xue Caiqiang, Zhang Bin, Ye Shue, Li Yumin
Department of Pathology, Lanzhou University Second Hospital, Lanzhou, Gansu 730000, P.R. China.
Department of Pathology, Chengdu First People's Hospital, Chengdu, Sichuan 610000, P.R. China.
Oncol Lett. 2025 Jan 7;29(3):120. doi: 10.3892/ol.2025.14867. eCollection 2025 Mar.
The atypical expression of immune phenotypes in lymphoma is often associated with a poor prognosis and presents diagnostic challenges. The present study reports on a rare extranodal NK/T cell lymphoma. In addition to typical morphology and immunohistochemical characteristics, these tumors strongly express CD20 and CD30 and partially express CD15, which is associated with aggressive clinical behavior. Differential diagnosis should be cautiously approached in extranodal NK/T cell lymphoma because the abovementioned markers are typically expressed in B cell lymphoma or Hodgkin's lymphoma. In addition to rigorous histological and comprehensive immunohistochemical staining, whole-body imaging and molecular testing can assist with diagnosis. In the present case, the patient died of multiple organ failure shortly after diagnosis. Lymphoma exhibits an atypical immunophenotype, thus emphasizing the importance of a thorough analysis of the interrelations among clinical, imaging and pathological features.
淋巴瘤中免疫表型的非典型表达通常与预后不良相关，并带来诊断挑战。本研究报告了一例罕见的结外NK/T细胞淋巴瘤。除了典型的形态学和免疫组化特征外，这些肿瘤强烈表达CD20和CD30，并部分表达CD15，这与侵袭性临床行为相关。在结外NK/T细胞淋巴瘤中进行鉴别诊断时应谨慎，因为上述标志物通常在B细胞淋巴瘤或霍奇金淋巴瘤中表达。除了严格的组织学检查和全面的免疫组化染色外，全身成像和分子检测有助于诊断。在本病例中，患者在诊断后不久死于多器官功能衰竭。淋巴瘤表现出非典型免疫表型，从而强调了全面分析临床、影像和病理特征之间相互关系的重要性。
