社区中的血管衰老表现与高血压
Vascular ageing manifestations and hypertension in the community.
作者信息
Alanis Guillermo A, Boutouyrie Pierre, Abouqateb Mouad, Bruno Rosa Maria, Climie Rachel E, van Sloten Thomas, Danchin Nicolas, Pannier Bruno, Laurent Stéphane, Jouven Xavier, Empana Jean-Philippe
机构信息
Université Paris Cité, INSERM U970, Paris Cardiovascular Research Centre, Team Integrative epidemiology of cardiovascular diseases, Paris, France.
Université Paris Cité, INSERM U970, Paris Cardiovascular Research Centre, Team Arterial diseases in women, Paris, France.
出版信息
Am J Prev Cardiol. 2024 Dec 13;21:100918. doi: 10.1016/j.ajpc.2024.100918. eCollection 2025 Mar.
OBJECTIVE
To investigate the association between joint manifestations of vascular ageing (VA) and hypertension.
METHODS
We used baseline (2008-2012) and follow-up data (up to 2024) from the Paris Prospective Study III, a French cohort of 10,157 participants. Prevalent and incident hypertension were determined at baseline (blood pressure ≥140/90 mmHg or on medication) and at 2, 4, 6, 8 and 10 years of follow-up (self-reported antihypertensive treatment). VA manifestations were assessed at baseline via echo-tracking in the right common carotid artery. Clustering analysis identified patterns of VA and their association with hypertension was assessed with logistic regression.
RESULTS
The cross-sectional analysis included 9,096 participants (mean age: 59±6 years, 39 % female). Hypertension prevalence was 36 % ( = 3,276). Three clusters of VA manifestations were identified. Cluster 1 ( = 4,326;47.6 %) was characterized by healthy vascular ageing (HVA), Cluster 2 by increased arteriosclerosis (ART) ( = 2,274;25.0 %) and Cluster 3 by greater atherosclerosis prevalence (ATH) ( = 2,496;27.4 %). Compared to the HVA cluster, ART (aOR 3.94; 95 % CI 3.50;4.45) and ATH clusters (aOR 2.69; 95 % CI 2.38;3.04) were associated with prevalent hypertension. The prospective analysis included 5,310 normotensives with 754 (14.1 %) cases of incident hypertension (median follow-up of 10.05 years [range: 10.00;10.15]). Both ART (aOR 1.34; 95 % CI 1.08;1.65) and ATH (aOR 1.70; 95 % CI 1.40;2.07) clusters were associated with incident hypertension.
CONCLUSION
Vascular ageing manifestations reflecting increased carotid arteriosclerosis and atherosclerosis are related to prevalent and incident hypertension.
目的
研究血管老化（VA）的关节表现与高血压之间的关联。
方法
我们使用了来自巴黎前瞻性研究III的基线数据（2008 - 2012年）和随访数据（截至2024年），这是一个由10157名参与者组成的法国队列。在基线时（血压≥140/90 mmHg或正在接受药物治疗）以及随访的第2、4、6、8和10年（自我报告的抗高血压治疗情况）确定高血压的患病率和发病率。通过右侧颈总动脉的回声跟踪在基线时评估VA表现。聚类分析确定了VA模式，并使用逻辑回归评估其与高血压的关联。
结果
横断面分析纳入了9096名参与者（平均年龄：59±6岁，39%为女性）。高血压患病率为36%（n = 3276）。确定了三组VA表现。第1组（n = 4326；47.6%）的特征是健康的血管老化（HVA），第2组为动脉硬化增加（ART）（n = 2274；25.0%），第3组为动脉粥样硬化患病率更高（ATH）（n = 2496；27.4%）。与HVA组相比，ART组（调整优势比[aOR] 3.94；95%置信区间[CI] 3.50；4.45）和ATH组（aOR 2.69；95% CI 2.38；3.04）与高血压患病率相关。前瞻性分析纳入了5310名血压正常者，其中754例（14.1%）发生高血压（中位随访时间为10.05年[范围：10.00；10.15]）。ART组（aOR 1.34；95% CI 1.08；1.65）和ATH组（aOR 1.70；95% CI 1.40；2.07）均与高血压发病率相关。
结论
反映颈动脉动脉硬化和动脉粥样硬化增加的血管老化表现与高血压的患病率和发病率相关。
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