Chatterjee Gourab, Saha Asit Kumar, Khurshid Shamama, Saha Achintya
Department of Food Technology, Haldia Institute of Technology, Haldia, India.
Department of Chemical Engineering, Haldia Institute of Technology, Haldia, India.
J Med Food. 2025 Apr;28(4):325-339. doi: 10.1089/jmf.2024.k.0149. Epub 2025 Jan 14.
Black cumin ( L.) (family Ranunculaceae) is a largely utilized therapeutic herb worldwide. This comprehensive review discusses the pharmacological benefits of black cumin seed oil, focusing on its bioactive component thymoquinone (TQ). The review is structured as follows: First, we examine the antimicrobial properties of black cumin oil, followed by an analysis of its antioxidant capabilities. Finally, we explore its therapeutic potential, particularly in neurodegenerative diseases and COVID-19. Phytochemicals from have exhibited potential for developing novel preventive and therapeutic strategies against jaundice, gastrointestinal disorders, skin diseases, anorexia, conjunctivitis, dyspepsia, intrinsic hemorrhage, amenorrhea, paralysis, anorexia, rheumatism, diabetes, hypertension, fever, influenza, eczema, asthma, cough, bronchitis, and headache. The broader spectrum of application for and its essential bioactives have certainly enhanced the commercial value of this seed oil. TQ, a major constituent of black cumin seed oil, has numerous beneficial properties. Researchers have extensively studied black cumin seed oil and its major component, TQ. These studies have revealed a wide range of pharmacological properties, including anticancer, immunomodulatory, analgesic, antimicrobial, antidiabetic, and anti-inflammatory effects. Additionally, TQ has shown neuroprotective, spasmolytic, bronchodilatory, hepatoprotective, renoprotective, gastroprotective, and antioxidant activities.
黑孜然（毛茛科）在全球范围内是一种广泛应用的治疗性草药。这篇综述讨论了黑孜然籽油的药理益处，重点关注其生物活性成分百里醌（TQ）。综述结构如下：首先，我们研究黑孜然油的抗菌特性，接着分析其抗氧化能力。最后，我们探讨其治疗潜力，特别是在神经退行性疾病和新冠肺炎方面。黑孜然中的植物化学物质已显示出开发针对黄疸、胃肠道疾病、皮肤病、厌食症、结膜炎、消化不良、内出血、闭经、瘫痪、厌食症、风湿病、糖尿病、高血压、发热、流感、湿疹、哮喘、咳嗽、支气管炎和头痛的新型预防和治疗策略的潜力。黑孜然及其重要生物活性成分更广泛的应用范围无疑提高了这种籽油的商业价值。TQ是黑孜然籽油的主要成分，具有许多有益特性。研究人员对黑孜然籽油及其主要成分TQ进行了广泛研究。这些研究揭示了广泛的药理特性，包括抗癌、免疫调节、镇痛、抗菌、抗糖尿病和抗炎作用。此外，TQ还表现出神经保护、解痉、支气管扩张、肝保护、肾保护、胃保护和抗氧化活性。
