Hymes S R, Morison W L, Farmer E R, Walters L L, Tutschka P J, Santos G W
J Am Acad Dermatol. 1985 Jan;12(1 Pt 1):30-7. doi: 10.1016/s0190-9622(85)70005-9.
Chronic cutaneous graft-versus-host reaction following bone marrow transplantation has been difficult to manage in some patients because of poor response to immunosuppressive agents or because of toxicity to these drugs. We recently used methoxsalen and ultraviolet A therapy and found it to be successful in controlling chronic cutaneous lichenoid graft-versus-host reaction in a bone marrow transplant patient. Although there was an initial flare of an eruption resembling acute cutaneous graft-versus-host reaction, both this acute eruption and the lichenoid lesions subsided and cleared with continued treatment. The skin lesions recurred when treatment was discontinued but responded promptly when it was initiated for the second time. Other than mild phototoxicity, there were no other significant side effects.
骨髓移植后慢性皮肤移植物抗宿主反应在一些患者中难以处理，原因是对免疫抑制剂反应不佳或这些药物存在毒性。我们最近使用甲氧沙林和紫外线A疗法，发现其成功控制了一名骨髓移植患者的慢性皮肤苔藓样移植物抗宿主反应。尽管最初有类似急性皮肤移植物抗宿主反应的皮疹发作，但随着持续治疗，这种急性皮疹和苔藓样病变都消退并清除了。治疗中断时皮肤病变复发，但再次开始治疗时迅速缓解。除了轻度光毒性外，没有其他明显的副作用。
