Janin-Mercier A, Saurat J H, Bourges M, Sohier J, Didierjean L, Gluckman E
Ann Dermatol Venereol. 1981;108(1):49-56.
An ultrastructural study was performed on skin biopsies of eight patients with lichenoid eruption of chronic graft-versus-host disease (GVHD). The lichenoid eruption is similar to idiopathic lichen planus with the injury of the basal cells, the distribution of the numerous colloid bodies, and the presence of regenerative cells. Lymphocytes satellites of injured keratinocytes were observed in those lichenoid eruptions, as well as in the acute phase of GVHD. The numerous mast cells in the lichenoid eruption of GVHD may be related to the connective tissue changes of the patients progressing to a late sclerotic phase of chronic GVHD.
对8例慢性移植物抗宿主病（GVHD）苔藓样疹患者的皮肤活检标本进行了超微结构研究。苔藓样疹类似于特发性扁平苔藓，存在基底细胞损伤、大量胶样小体分布以及再生细胞。在这些苔藓样疹以及GVHD急性期均观察到角质形成细胞周围的淋巴细胞卫星现象。GVHD苔藓样疹中大量肥大细胞可能与患者结缔组织变化进展至慢性GVHD晚期硬化阶段有关。
