Parada Humberto, Agalliu Ilir, Sotres-Alvarez Daniela, Olshan Andrew F, Evenson Kelly R, Rohan Thomas E, Kaplan Robert C, Thompson Caroline A, Gallo Linda C, Penedo Frank J, Cai Jianwen, Wassertheil-Smoller Sylvia, Thyagarajan Bharat, Thomas Stefani N, Garcia-Bedoya Olga L, Daviglus Martha L, Talavera Gregory A
Division of Epidemiology and Biostatistics, School of Public Health, San Diego State University, San Diego, California.
UC San Diego Health Moores Cancer Center, La Jolla, California.
Cancer Epidemiol Biomarkers Prev. 2025 Apr 3;34(4):491-499. doi: 10.1158/1055-9965.EPI-24-1325.
Few studies have examined how cancer incidence varies by the country of origin among US Hispanic/Latino adults. In this study, we describe the incidence rates (IR) of cancer overall and for screen-detectable, tobacco-related, and obesity-related cancers among 16,415 participants in the Hispanic Community Health Study/Study of Latinos, an ongoing population-based cohort study of Hispanic/Latino adults from diverse backgrounds.
Cohort participant records were linked to the state cancer registries in New York, Florida, California, and Illinois to ascertain cancer incidence from baseline (2008-2011) through 2021. We estimated weighted age-adjusted IRs and age- and sex-adjusted HRs.
Over a mean follow-up of 10.7 (SD = 2.0) years, 715 incident invasive cancers were diagnosed including 118 female breast, 102 prostate, and 79 bronchus and lung cancers. The IR of all cancers combined was 26.2 [95% confidence interval (CI), 22.6-30.2] per 10,000 (10K) person-years (py). The IRs were lowest among persons of Mexican descent [IR, 19.0 (95% CI, 15.0-24.1) per 10K py] and highest for those of Puerto Rican [IR, 36.6 (95% CI, 28.4-47.0) per 10K py] descent. Compared with those of Mexican descent, those of Puerto Rican, Cuban, and Dominican descent had higher hazards of cancer incidence; the incidence of obesity-related (HR, 2.37; 95% CI, 1.43-3.95) and tobacco-related (HR, 3.00; 95% CI, 1.58-5.71) cancers was also the highest among Puerto Ricans.
Cancer IRs varied by Hispanic/Latino heritage and were masked when Hispanics/Latinos were aggregated into a single group.
Understanding disparities in cancer risk by Hispanic/Latino heritage may help tailor cancer prevention and control strategies.
很少有研究探讨美国西班牙裔/拉丁裔成年人的癌症发病率如何因原籍国而异。在本研究中，我们描述了西班牙裔社区健康研究/拉丁裔研究中16415名参与者的总体癌症发病率以及可通过筛查发现的、与烟草相关的和与肥胖相关的癌症的发病率，该研究是一项正在进行的基于人群的队列研究，研究对象是来自不同背景的西班牙裔/拉丁裔成年人。
队列参与者的记录与纽约、佛罗里达、加利福尼亚和伊利诺伊州的州癌症登记处相链接，以确定从基线（2008 - 2011年）到2021年的癌症发病率。我们估计了加权年龄调整发病率和年龄及性别调整风险比。
在平均10.7（标准差 = 2.0）年的随访期内，共诊断出715例侵袭性癌症病例，其中包括118例女性乳腺癌、102例前列腺癌和79例支气管肺癌。所有癌症合并的发病率为每10000人年26.2 [95%置信区间（CI），22.6 - 30.2]。发病率在墨西哥裔人群中最低[发病率，每10000人年19.0（95% CI，15.0 - 24.1）]，在波多黎各裔人群中最高[发病率，每10000人年36.6（95% CI，28.4 - 47.0）]。与墨西哥裔相比，波多黎各裔、古巴裔和多米尼加裔人群患癌症的风险更高；与肥胖相关的癌症（风险比，2.37；95% CI，1.43 - 3.95）和与烟草相关的癌症（风险比，3.00；95% CI，1.58 - 5.71）的发病率在波多黎各人中也最高。
癌症发病率因西班牙裔/拉丁裔血统而异，当西班牙裔/拉丁裔被合并为一个单一群体时，这种差异被掩盖了。
了解西班牙裔/拉丁裔血统在癌症风险方面的差异可能有助于制定针对性的癌症预防和控制策略。
