Stern Dalia, Gomez-Flores-Ramos Liliana, Trabert Britton, Setiawan V Wendy, Le Marchand Loïc, Gomez Henry, Scheet Paul A, Parada Humberto, Pirzada Amber, Lajous Martin, Farland Leslie V
SECIHTI - Center for Research on Population Health, National Institute of Public Health, Fray Pedro de Gante 12, Belisario Domínguez Secc 16, Tlalpan, 14080, Ciudad de México, Mexico.
Department of Obstetrics and Gynecology, University of Utah, and Huntsman Cancer Institute at the University of Utah, 30 N 1900 E, Salt Lake City, UT, 84132, USA.
Cancer Causes Control. 2025 Apr 17. doi: 10.1007/s10552-025-02000-8.
Hispanics have been historically underrepresented in epidemiologic cancer research. Existing cohort studies focused on recruiting Hispanic participants have been relatively small, making studying cancer outcomes challenging. Therefore, we aimed to compare the distribution of cancer risk factors among Hispanic women of Mexican heritage (HWMH) participating in existing cohorts to explore the possibility of future data pooling efforts.
We used baseline data of HWMH from three US-based studies, the Mexican American Cohort (MAC; n = 19,797; 2001-2017), the Multiethnic Cohort (MEC; n = 18,007; 1993-1996), and the Hispanic Community Health Study/Study of Latinos (HCHS/SOL; n = 4,022; 2008-2011), and one study from Mexico, the Mexican Teachers' Cohort (MTC; n = 115,275; 2006-2008).
Participants in MEC (59.5y) were older on average than MAC (40.9y), HCHS/SOL (45.5y), and MTC (42.6y) at enrollment. Most MAC (77.6%) and HCHS/SOL (85.4%) participants spoke Spanish as their primary language. Age at menarche (12.5-13.1y), age at menopause (45.8-47.9y), and smoking prevalence (~ 10%) was similar across studies. Parity was higher in MAC (3.8) and MEC (4.1) compared to HCHS/SOL (3.2) and MTC (2.5). Ever use of oral contraceptives was more frequent in HCHS/SOL (63.5%) compared to MTC (45.6%), MAC (37.9%), and MEC (35.2%). Obesity, diabetes, and hypertension were more common in the US cohorts.
This comparative study demonstrates the ability to harmonize data and provide information for future pooling projects across cohorts to evaluate cancer outcomes. Similarities and differences in characteristics across cohorts can be leveraged to better understand health disparities in HWMH.
在癌症流行病学研究中，西班牙裔人群的代表性一直不足。现有的针对招募西班牙裔参与者的队列研究规模相对较小，这使得研究癌症结局具有挑战性。因此，我们旨在比较参与现有队列研究的墨西哥裔西班牙裔女性（HWMH）中癌症风险因素的分布情况，以探索未来数据合并工作的可能性。
我们使用了来自美国三项研究的HWMH基线数据，即墨西哥裔美国人队列（MAC；n = 19,797；2001 - 2017年）、多族裔队列（MEC；n = 18,007；1993 - 1996年）和西班牙裔社区健康研究/拉丁裔研究（HCHS/SOL；n = 4,022；2008 - 2011年），以及来自墨西哥的一项研究，即墨西哥教师队列（MTC；n = 115,275；2006 - 2008年）。
MEC的参与者（59.5岁）在入组时的平均年龄比MAC（40.9岁）、HCHS/SOL（45.5岁）和MTC（42.6岁）的参与者大。大多数MAC（77.6%）和HCHS/SOL（85.4%）的参与者以西班牙语为主要语言。初潮年龄（12.5 - 13.1岁）、绝经年龄（45.8 - 47.9岁）和吸烟率（约10%）在各项研究中相似。MAC（3.8）和MEC（4.1）的产次高于HCHS/SOL（3.2）和MTC（2.5）。与MTC（45.6%）、MAC（37.9%）和MEC（35.2%）相比，HCHS/SOL（63.5%）中口服避孕药的使用频率更高。肥胖、糖尿病和高血压在美国的队列中更为常见。
这项比较研究证明了整合数据的能力，并为未来跨队列评估癌症结局的合并项目提供信息。可以利用各队列特征的异同来更好地理解HWMH中的健康差异。
