Li Junhua, He Min, Zhou Yu
School of Mathematics and Computer Science, Hanjiang Normal University, Shiyan, Hubei, China.
Department of Respiratory and Critical Care Medicine, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, China.
PLoS One. 2025 Jan 14;20(1):e0314594. doi: 10.1371/journal.pone.0314594. eCollection 2025.
Overactive bladder (OAB) is a common disorder, particularly in women, and its symptoms, including urgency, frequency, and nocturia, can significantly affect quality of life. The cardiometabolic index (CMI) is a novel metabolic risk indicator that has been receiving more attention lately. This study investigated the association between CMI and OAB in adult women.
A cross-sectional analysis was performed using data from the National Health and Nutrition Examination Survey (NHANES) covering the years 2007 to 2018, including 6323 female participants. CMI was calculated based on waist-to-height ratio, triglyceride, and HDL cholesterol levels, while OAB was assessed using the overactive bladder symptom score (OABSS). The association between CMI and OAB was evaluated through multivariate logistic regression, generalized additive models (GAM), smoothing curve fitting, and subgroup analysis. We finally included male participants for sensitivity analysis.
A significant positive association was found between female CMI and OAB prevalence (OR = 1.46, 95% CI: 1.29-1.65). When compared to the lowest CMI quartile (Q1), women in the highest CMI quartile were 70% more likely to have OAB (OR = 1.70, 95% CI: 1.42-2.04). Smoothed curve fitting analysis showed a linear association between CMI and OAB. Subgroup analysis revealed that the association between CMI and OAB was stronger in women aged 20-50 years as well as in women without hypertension. Sensitivity analysis confirmed the robustness of our result.
CMI was significantly and positively associated with the prevalence of OAB, especially in women aged 20-50 years without hypertension. This finding provides a new perspective on metabolic risk management and may contribute to the early prevention and improvement of bladder function in women.
膀胱过度活动症（OAB）是一种常见疾病，在女性中尤为常见，其症状包括尿急、尿频和夜尿症，会显著影响生活质量。心脏代谢指数（CMI）是一种新型代谢风险指标，近来受到越来越多的关注。本研究调查了成年女性中CMI与OAB之间的关联。
使用2007年至2018年美国国家健康与营养检查调查（NHANES）的数据进行横断面分析，包括6323名女性参与者。CMI根据腰高比、甘油三酯和高密度脂蛋白胆固醇水平计算得出，而OAB则使用膀胱过度活动症症状评分（OABSS）进行评估。通过多因素逻辑回归、广义相加模型（GAM）、平滑曲线拟合和亚组分析评估CMI与OAB之间的关联。我们最终纳入男性参与者进行敏感性分析。
发现女性CMI与OAB患病率之间存在显著正相关（OR = 1.46，95%CI：1.29 - 1.65）。与CMI最低四分位数（Q1）相比，CMI最高四分位数的女性患OAB的可能性高70%（OR = 1.70，95%CI：1.42 - 2.04）。平滑曲线拟合分析显示CMI与OAB之间存在线性关联。亚组分析显示，CMI与OAB之间的关联在20 - 50岁女性以及无高血压女性中更强。敏感性分析证实了我们结果的稳健性。
CMI与OAB患病率显著正相关，尤其是在20 - 50岁无高血压的女性中。这一发现为代谢风险管理提供了新视角，可能有助于女性膀胱功能的早期预防和改善。
