Angeli Peter A, DiNicola Lauren M, Saadon-Grosman Noam, Eldaief Mark C, Buckner Randy L
Department of Psychology, Center for Brain Science, Harvard University, Cambridge, MA 02138.
Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA 02129.
Proc Natl Acad Sci U S A. 2025 Jan 21;122(3):e2422083122. doi: 10.1073/pnas.2422083122. Epub 2025 Jan 14.
The hippocampus possesses anatomical differences along its long axis. Here, we explored the functional specialization of the human hippocampal long axis using network-anchored precision functional MRI in two independent datasets (N = 11 and N = 9) paired with behavioral analysis (N = 266 and N = 238). Functional connectivity analyses demonstrated that the anterior hippocampus was preferentially correlated with a cerebral network associated with remembering, while the posterior hippocampus selectively contained a region correlated with a distinct network associated with behavioral salience. Seed regions placed within the hippocampus recapitulated the distinct cerebral networks. Functional characterization of the anterior and posterior hippocampal regions using task data identified and replicated a functional double dissociation. The anterior hippocampal region was sensitive to remembering and imagining the future, specifically tracking the process of scene construction, while the posterior hippocampal region displayed transient responses to targets in an oddball detection task and to transitions between task blocks. These findings suggest an unexpected specialization along the long axis of the human hippocampus with differential responses reflecting the functional properties of the partner cerebral networks.
海马体在其长轴上存在解剖学差异。在此，我们使用网络锚定的精准功能磁共振成像技术，在两个独立数据集（N = 11和N = 9）中结合行为分析（N = 266和N = 238），探索了人类海马体长轴的功能特化。功能连接分析表明，海马体前部优先与一个与记忆相关的脑网络相关联，而后部海马体则选择性地包含一个与行为显著性相关的不同网络的相关区域。置于海马体内的种子区域重现了不同的脑网络。使用任务数据对海马体前后区域进行功能表征，识别并重复了一种功能双重分离。海马体前部区域对记忆和想象未来敏感，特别追踪场景构建过程，而后部海马体区域在奇偶数检测任务中对目标以及任务块之间的转换表现出瞬时反应。这些发现表明，人类海马体长轴存在意想不到的特化，不同反应反映了相关脑网络的功能特性。
