Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110;
Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110.
Proc Natl Acad Sci U S A. 2021 Aug 24;118(34). doi: 10.1073/pnas.2101743118.
The hippocampus is critically important for a diverse range of cognitive processes, such as episodic memory, prospective memory, affective processing, and spatial navigation. Using individual-specific precision functional mapping of resting-state functional MRI data, we found the anterior hippocampus (head and body) to be preferentially functionally connected to the default mode network (DMN), as expected. The hippocampal tail, however, was strongly preferentially functionally connected to the parietal memory network (PMN), which supports goal-oriented cognition and stimulus recognition. This anterior-posterior dichotomy of resting-state functional connectivity was well-matched by differences in task deactivations and anatomical segmentations of the hippocampus. Task deactivations were localized to the hippocampal head and body (DMN), relatively sparing the tail (PMN). The functional dichotomization of the hippocampus into anterior DMN-connected and posterior PMN-connected parcels suggests parallel but distinct circuits between the hippocampus and medial parietal cortex for self- versus goal-oriented processing.
海马体对于各种认知过程至关重要，例如情景记忆、前瞻性记忆、情感处理和空间导航。使用个体特异性的静息态功能磁共振成像数据的精确功能映射，我们发现正如预期的那样，前海马体（头部和体部）优先与默认模式网络（DMN）进行功能连接。然而，海马尾部与顶叶记忆网络（PMN）强烈优先进行功能连接，PMN 支持有目标的认知和刺激识别。这种静息状态功能连接的前后二分法与海马体的任务去激活和解剖分割差异很好地匹配。任务去激活定位于海马体的头部和体部（DMN），相对地保留了尾部（PMN）。海马体的功能二分法分为与 DMN 相连的前部分和与 PMN 相连的后部分，这表明海马体和内侧顶叶皮层之间存在平行但不同的用于自我导向和目标导向处理的回路。
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