• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Platelet potential to switch to procoagulant phenotype compensates bleeding tendency in patients with hemophilia A.

作者信息

Althaus Karina, Kieninger Sophie, Bäuerle Anna, Hammer Stefanie, Wolska Nina, Uzun Günalp, Weich Karoline, Alberio Lorenzo, Aliotta Alessandro, Faul Christoph, Moyses Margarete, Holzer Ursula, Icheva Vanya, Gorodezki David, Hörber Sebastian, Halimeh Susan, Zlamal Jan, Bakchoul Tamam

机构信息

Institute for Clinical and Experimental Transfusion Medicine, Medical Faculty of Tuebingen, University Hospital Tuebingen, Tuebingen, Germany.

Center for Clinical Transfusion Medicine, University Hospital Tuebingen, Tuebingen, Germany.

出版信息

Blood Adv. 2025 Mar 11;9(5):1181-1184. doi: 10.1182/bloodadvances.2024014785.

DOI:10.1182/bloodadvances.2024014785
PMID:39808801
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11925503/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c949/11925503/1446bf304f1d/BLOODA_ADV-2024-014785-gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c949/11925503/dbd1f722d32f/BLOODA_ADV-2024-014785-ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c949/11925503/4b0b1a49ef37/BLOODA_ADV-2024-014785-gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c949/11925503/1446bf304f1d/BLOODA_ADV-2024-014785-gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c949/11925503/dbd1f722d32f/BLOODA_ADV-2024-014785-ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c949/11925503/4b0b1a49ef37/BLOODA_ADV-2024-014785-gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c949/11925503/1446bf304f1d/BLOODA_ADV-2024-014785-gr2.jpg

相似文献

1
Platelet potential to switch to procoagulant phenotype compensates bleeding tendency in patients with hemophilia A.血友病A患者血小板转变为促凝血表型的潜能可补偿出血倾向。
Blood Adv. 2025 Mar 11;9(5):1181-1184. doi: 10.1182/bloodadvances.2024014785.
2
Platelets and hemophilia: A review of the literature.血小板与血友病：文献综述。
Thromb Res. 2017 Jul;155:131-139. doi: 10.1016/j.thromres.2017.05.013. Epub 2017 May 13.
3
Levels of procoagulant microparticles expressing phosphatidylserine contribute to bleeding phenotype in patients with inherited thrombocytopenia.表达磷脂酰丝氨酸的促凝微粒水平导致遗传性血小板减少症患者的出血表型。
Blood Coagul Fibrinolysis. 2021 Oct 1;32(7):480-490. doi: 10.1097/MBC.0000000000001080.
4
Severe hemophilia with mild bleeding phenotype: molecular characterization and global coagulation profile.严重血友病伴轻度出血表型：分子特征和全球凝血谱。
J Thromb Haemost. 2010 Apr;8(4):737-43. doi: 10.1111/j.1538-7836.2010.03767.x. Epub 2009 Jan 21.
5
Thrombin generation and implications for hemophilia therapies: A narrative review.凝血酶生成及其对血友病治疗的影响：一篇叙述性综述。
Res Pract Thromb Haemost. 2022 Dec 21;7(1):100018. doi: 10.1016/j.rpth.2022.100018. eCollection 2023 Jan.
6
Platelet degranulation and glycoprotein IIbIIIa opening are not related to bleeding phenotype in severe haemophilia A patients.
Thromb Haemost. 2014 Jun;111(6):1022-30. doi: 10.1160/TH13-07-0546. Epub 2014 Jan 30.
7
Patients with moderate hemophilia A and B with a severe bleeding phenotype have an increased burden of disease.患有严重出血表型的中度甲型和乙型血友病患者的疾病负担增加。
J Thromb Haemost. 2024 Jan;22(1):152-162. doi: 10.1016/j.jtha.2023.09.029. Epub 2023 Oct 7.
8
Enhanced in vitro procoagulant and antifibrinolytic potential of superactive variants of recombinant factor VIIa in severe hemophilia A.重组凝血因子VIIa超活性变体在重度A型血友病中增强的体外促凝血和抗纤维蛋白溶解潜能
J Thromb Haemost. 2003 Oct;1(10):2175-8. doi: 10.1046/j.1538-7836.2003.00444.x.
9
Identification of a novel mutation in HPS6 in a patient with hemophilia B and oculocutaneous albinism.一名患有乙型血友病和眼皮肤白化病患者中HPS6新突变的鉴定。
Mol Genet Metab. 2016 Nov;119(3):284-287. doi: 10.1016/j.ymgme.2016.08.009. Epub 2016 Sep 3.
10
A novel technique to characterize procoagulant platelet formation and evaluate platelet procoagulant tendency in cats by flow cytometry.一种通过流式细胞术表征促凝血血小板形成并评估猫血小板促凝血倾向的新技术。
Front Vet Sci. 2024 Dec 16;11:1480756. doi: 10.3389/fvets.2024.1480756. eCollection 2024.

本文引用的文献

1
Biophysical characterization of blood coagulation factor VIII binding to lipid nanodiscs that mimic activated platelet surfaces.模拟活化血小板表面的脂质纳米盘结合凝血因子VIII的生物物理特性研究
J Thromb Haemost. 2025 Feb;23(2):513-524. doi: 10.1016/j.jtha.2024.11.003. Epub 2024 Nov 15.
2
Suppressed ORAI1-STIM1-dependent Ca entry by protein kinase C isoforms regulating platelet procoagulant activity.蛋白激酶C亚型通过调节血小板促凝血活性抑制ORAI1-STIM1依赖性钙内流。
J Biol Chem. 2024 Dec;300(12):107899. doi: 10.1016/j.jbc.2024.107899. Epub 2024 Oct 17.
3
Platelet phosphatidylserine is the critical mediator of thrombosis in heparin-induced thrombocytopenia.
血小板磷脂酰丝氨酸是肝素诱导的血小板减少症中血栓形成的关键介质。
Haematologica. 2023 Oct 1;108(10):2690-2702. doi: 10.3324/haematol.2022.282275.
4
Update on platelet procoagulant mechanisms in health and in bleeding disorders.血小板促凝机制在健康和出血性疾病中的研究进展。
Int J Lab Hematol. 2022 Sep;44 Suppl 1:89-100. doi: 10.1111/ijlh.13866.
5
Health issues in women and girls affected by haemophilia with a focus on nomenclature, heavy menstrual bleeding, and musculoskeletal issues.受血友病影响的妇女和女孩的健康问题，重点是命名法、月经过多和肌肉骨骼问题。
Haemophilia. 2022 May;28 Suppl 4(Suppl 4):18-25. doi: 10.1111/hae.14535.
6
Procoagulant platelet sentinels prevent inflammatory bleeding through GPIIBIIIA and GPVI.促凝血小板哨兵通过 GPIb-IX-V 和 GPIb-VI 防止炎症性出血。
Blood. 2022 Jul 14;140(2):121-139. doi: 10.1182/blood.2021014914.
7
Low COAT platelets are frequent in patients with bleeding disorders of unknown cause (BDUC) and can be enhanced by DDAVP.低COAT血小板在不明原因出血性疾病（BDUC）患者中很常见，且可通过去氨加压素增强。
J Thromb Haemost. 2022 May;20(5):1271-1274. doi: 10.1111/jth.15687. Epub 2022 Mar 13.
8
Thrombocytopathies: Not Just Aggregation Defects-The Clinical Relevance of Procoagulant Platelets.血小板病：不仅仅是聚集缺陷——促凝血血小板的临床相关性
J Clin Med. 2021 Feb 24;10(5):894. doi: 10.3390/jcm10050894.
9
Platelet calcium signaling by G-protein coupled and ITAM-linked receptors regulating anoctamin-6 and procoagulant activity.G 蛋白偶联受体和 ITAM 连接受体调节 ANO6 和促凝活性的血小板钙信号转导。
Platelets. 2021 Oct 3;32(7):863-871. doi: 10.1080/09537104.2020.1859103. Epub 2020 Dec 26.
10
Sodium-Calcium Exchanger Reverse Mode Sustains Dichotomous Ion Fluxes Required for Procoagulant COAT Platelet Formation.钠钙交换蛋白反向转运模式维持促凝 COAT 血小板形成所需的二分离子流。
Thromb Haemost. 2021 Mar;121(3):309-321. doi: 10.1055/s-0040-171670. Epub 2020 Oct 24.