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1
Low COAT platelets are frequent in patients with bleeding disorders of unknown cause (BDUC) and can be enhanced by DDAVP.低COAT血小板在不明原因出血性疾病(BDUC)患者中很常见,且可通过去氨加压素增强。
J Thromb Haemost. 2022 May;20(5):1271-1274. doi: 10.1111/jth.15687. Epub 2022 Mar 13.
2
1-Deamino-8-D-arginine vasopressin as a therapy for the bleeding diathesis of renal failure.1-去氨基-8-D-精氨酸加压素作为肾衰竭出血素质的一种治疗方法。
Am J Nephrol. 1984;4(1):49-51. doi: 10.1159/000166773.
3
1-deamino-8-D-arginine vasopressin (DDAVP) normalized the bleeding time in patients with platelet disorder characterized by defective calcium ionophore-induced platelet aggregation.
Br J Haematol. 2003 Sep;122(5):870-1. doi: 10.1046/j.1365-2141.2003.04508.x.
4
Effect of 1-deamino-8-D-arginine vasopressin on the prolonged bleeding time in chronic renal failure.1-去氨基-8-D-精氨酸加压素对慢性肾衰竭患者出血时间延长的影响。
Nephron. 1982;32(1):49-52. doi: 10.1159/000182801.
5
Bleeding times and DDAVP.
Reg Anesth. 1996 Sep-Oct;21(5):496-8.
6
1-Deamino-8-d-arginine vasopressin (DDAVP): a potential new treatment for the bleeding diathesis of acute renal failure.
Pharmatherapeutica. 1984;3(9):618-22.
7
[Desmopressin in the treatment of hemorrhagic diathesis].[去氨加压素治疗出血性素质]
Ugeskr Laeger. 1995 Nov 27;157(48):6713-5.
8
[DDAVP: biological effect and clinical utility].[去氨加压素:生物学效应及临床应用]
Sangre (Barc). 1994 Apr;39(2):121-5.
9
Shortening of bleeding time by 1-deamino-8-arginine vasopressin (DDAVP) in the absence of platelet von Willebrand factor in Gray platelet syndrome.在灰色血小板综合征中,缺乏血小板血管性血友病因子时1-去氨基-8-精氨酸加压素(DDAVP)对出血时间的缩短作用。
Thromb Haemost. 1987 Dec 18;58(4):1060-3.
10
DDAVP--the multipotent drug in patients with coagulopathies.
Transfus Med Rev. 1991 Apr;5(2):132-44. doi: 10.1016/s0887-7963(91)70200-9.

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Platelet potential to switch to procoagulant phenotype compensates bleeding tendency in patients with hemophilia A.血友病A患者血小板转变为促凝血表型的潜能可补偿出血倾向。
Blood Adv. 2025 Mar 11;9(5):1181-1184. doi: 10.1182/bloodadvances.2024014785.
2
Discriminating young platelets on human leukocyte antigen-I expression highlights their extremely high reactivity potential.根据人类白细胞抗原-I表达来区分年轻血小板,凸显了它们极高的反应潜能。
Res Pract Thromb Haemost. 2023 Feb 14;7(1):100006. doi: 10.1016/j.rpth.2022.100006. eCollection 2023 Jan.
3
Procoagulant platelets: novel players in thromboinflammation.促凝血小板:血栓炎症中的新角色。
Am J Physiol Cell Physiol. 2022 Oct 1;323(4):C951-C958. doi: 10.1152/ajpcell.00252.2022. Epub 2022 Aug 22.

本文引用的文献

1
How I treat bleeding disorder of unknown cause.我如何治疗原因不明的出血性疾病。
Blood. 2021 Nov 11;138(19):1795-1804. doi: 10.1182/blood.2020010038.
2
Thrombocytopathies: Not Just Aggregation Defects-The Clinical Relevance of Procoagulant Platelets.血小板病:不仅仅是聚集缺陷——促凝血血小板的临床相关性
J Clin Med. 2021 Feb 24;10(5):894. doi: 10.3390/jcm10050894.
3
Sodium-Calcium Exchanger Reverse Mode Sustains Dichotomous Ion Fluxes Required for Procoagulant COAT Platelet Formation.钠钙交换蛋白反向转运模式维持促凝 COAT 血小板形成所需的二分离子流。
Thromb Haemost. 2021 Mar;121(3):309-321. doi: 10.1055/s-0040-171670. Epub 2020 Oct 24.
4
Bleeding of unknown cause and unclassified bleeding disorders; diagnosis, pathophysiology and management.不明原因出血和未分类出血性疾病;诊断、病理生理学和管理。
Haemophilia. 2020 Nov;26(6):946-957. doi: 10.1111/hae.14174. Epub 2020 Oct 23.
5
Flow Cytometric Monitoring of Dynamic Cytosolic Calcium, Sodium, and Potassium Fluxes Following Platelet Activation.血小板激活后动态胞质钙、钠和钾通量的流式细胞术监测
Cytometry A. 2020 Sep;97(9):933-944. doi: 10.1002/cyto.a.24017. Epub 2020 Apr 27.
6
Supramaximal calcium signaling triggers procoagulant platelet formation.超最大钙信号触发促凝血血小板形成。
Blood Adv. 2020 Jan 14;4(1):154-164. doi: 10.1182/bloodadvances.2019000182.
7
Diagnostic utility of the ISTH bleeding assessment tool in patients with suspected platelet function disorders.ISTH 出血评估工具在疑似血小板功能障碍患者中的诊断效用。
J Thromb Haemost. 2019 Jul;17(7):1104-1112. doi: 10.1111/jth.14454. Epub 2019 May 22.
8
Diagnostic challenges of inherited mild bleeding disorders: a bait for poorly explored clinical and basic research.遗传性轻度出血性疾病的诊断挑战:未充分探索的临床和基础研究的诱饵。
J Thromb Haemost. 2019 Feb;17(2):257-270. doi: 10.1111/jth.14363. Epub 2019 Jan 21.
9
Procoagulant platelets: generation, function, and therapeutic targeting in thrombosis.促凝血小板:血栓形成中的生成、功能和治疗靶点。
Blood. 2017 Nov 16;130(20):2171-2179. doi: 10.1182/blood-2017-05-787259. Epub 2017 Sep 27.
10
Delayed-onset of procoagulant signalling revealed by kinetic analysis of COAT platelet formation.通过对 COAT 血小板形成的动力学分析揭示出促凝信号的延迟发生。
Thromb Haemost. 2017 Jun 2;117(6):1101-1114. doi: 10.1160/TH16-09-0711. Epub 2017 Apr 6.

Low COAT platelets are frequent in patients with bleeding disorders of unknown cause (BDUC) and can be enhanced by DDAVP.

作者信息

Segot Amandine, Adler Marcel, Aliotta Alessandro, Matthey-Guirao Elena, Nagler Michael, Bertaggia Calderara Debora, Grandoni Francesco, Gomez Francisco J, Alberio Lorenzo

机构信息

Division of Hematology and Central Hematology Laboratory, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.

Department of Clinical Chemistry, Inselspital, Bern University Hospital, University of Bern (UNIBE), Bern, Switzerland.

出版信息

J Thromb Haemost. 2022 May;20(5):1271-1274. doi: 10.1111/jth.15687. Epub 2022 Mar 13.

DOI:10.1111/jth.15687
PMID:35243754
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9314658/
Abstract
摘要