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对输血传播感染检测呈阳性的献血者的通知。

Notification of blood donors who test positive for transfusion-transmissible infections.

作者信息

O'Brien Sheila F, Naicker Kiyuri, Osmond Lori, Holloway Kelly, Drews Steven J, Bigham Mark, Goldman Mindy

机构信息

Epidemiology & Surveillance, Canadian Blood Services, Ottawa, Ontario, Canada.

School of Epidemiology & Public Health, University of Ottawa, Ottawa, Ontario, Canada.

出版信息

Vox Sang. 2025 Apr;120(4):394-400. doi: 10.1111/vox.13796. Epub 2025 Jan 14.

DOI:10.1111/vox.13796
PMID:39809317
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12017946/
Abstract

BACKGROUND AND OBJECTIVES

Despite screening procedures, a few blood donors confirm positive for transfusion-transmissible infections and are deferred. Effective notification of laboratory results is essential to ensure that donors are advised of confirmed results and to seek medical care. Here we report results from post-notification interviews of Canadian Blood Services donors.

MATERIALS AND METHODS

Over 17 years, 2006-2022, all donors with confirmed positive results for hepatitis B virus (HBV), hepatitis C virus (HCV), human T-cell lymphotropic virus (HTLV) and syphilis were notified by registered mail of their result and advised to see a physician. In a separate communication, all donors were later invited to participate in a scripted interview asking whether they tested positive for an infection; if yes, which one, what their reaction was, whether they consulted a physician and whether public health contacted them. Frequencies of responses were calculated.

RESULTS

Of 2654 donors with confirmed positive test results, 876 (33%) participated; 90% said they were informed of a positive test result. Of these, about a quarter did not know for which infection they were positive. Most were surprised, and some were sad or disappointed. Most saw a physician after notification (77%). About two-thirds with HBV or HCV said they were contacted by public health, slightly fewer (58%) with syphilis, 27% of those with HTLV.

CONCLUSION

Most donors recalled being notified and were aware of their positive test, but details of the infection were sometimes not understood or recalled, and not all donors consulted a physician about the infection.

摘要

背景与目的

尽管有筛查程序,但仍有少数献血者被确诊为输血传播感染并被延期献血。有效地通知实验室检测结果对于确保告知献血者确诊结果并促使其寻求医疗护理至关重要。在此,我们报告加拿大血液服务中心对献血者进行通知后访谈的结果。

材料与方法

在2006年至2022年的17年期间,所有被确诊为乙肝病毒(HBV)、丙肝病毒(HCV)、人类嗜T淋巴细胞病毒(HTLV)感染及梅毒阳性的献血者均通过挂号信被告知检测结果,并被建议去看医生。在另一次沟通中,所有献血者随后被邀请参加一次有脚本的访谈,询问他们是否检测出感染呈阳性;如果是,是哪种感染,他们的反应是什么,是否咨询过医生以及公共卫生部门是否联系过他们。计算了回答的频率。

结果

在2654名检测结果确诊为阳性的献血者中,876人(33%)参与了访谈;90%的人表示他们被告知检测结果呈阳性。其中,约四分之一的人不知道自己感染了哪种病毒。大多数人感到惊讶,有些人感到悲伤或失望。大多数人在收到通知后去看了医生(77%)。约三分之二感染HBV或HCV的人表示公共卫生部门联系过他们,感染梅毒的人中这一比例略低(58%),感染HTLV的人中这一比例为27%。

结论

大多数献血者回忆起收到了通知并知晓自己检测呈阳性,但有时对感染的细节并不理解或记不清,而且并非所有献血者都就感染问题咨询过医生。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14dd/12017946/a6b6bf8e7035/VOX-120-394-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14dd/12017946/a6b6bf8e7035/VOX-120-394-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14dd/12017946/a6b6bf8e7035/VOX-120-394-g001.jpg

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本文引用的文献

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BMC Public Health. 2024 Aug 27;24(1):2319. doi: 10.1186/s12889-024-19790-2.
2
Higher rates of laboratory-confirmed cases of syphilis in Western Canadian blood donors compared with Eastern Canadian blood donors following a period of societal re-opening.在社会重新开放一段时间后,与加拿大东部的献血者相比,加拿大西部的献血者中实验室确诊的梅毒病例比例更高。
Vox Sang. 2024 Oct;119(10):1116-1121. doi: 10.1111/vox.13715. Epub 2024 Jul 24.
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Implementation of sexual risk behavior donor screening in Canada.
加拿大实施性行为风险捐血者筛查。
Transfusion. 2024 Jul;64(7):1254-1261. doi: 10.1111/trf.17878. Epub 2024 May 17.
4
Prevalence of human T-cell lymphotropic virus-1/2 in Canada over 33 years: A unique contribution of blood donors to public health surveillance.33年来加拿大人类嗜T细胞病毒1型/2型的流行情况:献血者对公共卫生监测的独特贡献
Can J Public Health. 2024 Aug;115(4):611-621. doi: 10.17269/s41997-024-00886-6. Epub 2024 May 14.
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Notification and follow-up of blood donors reactive for transfusion-transmitted infections: A narrative review of the literature from India.献血者输血传播感染反应的通知和随访:来自印度的文献叙述性综述。
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