Amiri Mehdi, Mahmood Niaz, Tahmasebi Soroush, Sonenberg Nahum
Department of Biochemistry, McGill University, Montreal, QC H3G 1Y6, Canada.
Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, QC H3A 1A3, Canada.
RNA. 2025 Feb 19;31(3):416-428. doi: 10.1261/rna.080340.124.
Messenger RNA (mRNA) translational control plays a pivotal role in regulating cellular proteostasis under physiological and pathological conditions. Dysregulated mRNA translation is pervasive in cancer, in which protein synthesis is elevated to support accelerated cell growth and proliferation. Consequently, targeting the mRNA translation machinery has emerged as a therapeutic strategy to treat cancer. In this Perspective, we summarize the current knowledge of translation dysregulation in cancer, with emphasis on the eukaryotic translation initiation factor 4F complex. We outline recent endeavors to apply this knowledge to develop novel treatment strategies to combat cancer.
信使核糖核酸（mRNA）翻译控制在生理和病理条件下调节细胞蛋白质稳态中起着关键作用。mRNA翻译失调在癌症中普遍存在，其中蛋白质合成增加以支持加速的细胞生长和增殖。因此，靶向mRNA翻译机制已成为一种治疗癌症的策略。在这篇观点文章中，我们总结了目前关于癌症中翻译失调的知识，重点是真核翻译起始因子4F复合物。我们概述了最近为应用这些知识开发对抗癌症的新治疗策略所做的努力。
