Engelke Milena, Simões Jorge Piano, Basso Laura, Wunder Nina, Langguth Berthold, Probst Thomas, Pryss Rüdiger, Schlee Winfried
Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany.
Department of Psychology, Health and Technology, University of Twente, Enschede, The Netherlands.
NPJ Digit Med. 2025 Jan 14;8(1):27. doi: 10.1038/s41746-024-01425-w.
Intensive longitudinal sampling enhances subjective data collection by capturing real-time, dynamic inputs in natural settings, complementing traditional methods. This study evaluates the feasibility of using daily self-reported app data to assess clinical improvement among tinnitus patients undergoing treatment. App data from a multi-center randomized clinical trial were analysed using time-series feature extraction and nested cross-validated ordinal regression with elastic net regulation to predict clinical improvement based on the Clinical Global Impression-Improvement scale (CGI-I). With 50% app compliance (N = 129, 8480 entries), the model demonstrated good fit to the test data (McFadden R2 = 0.82) suggesting its generalizability. Clinical improvement was associated with linear declines in tinnitus-related thoughts, jaw tension, tinnitus loudness, increases in happiness, and variability changes in tinnitus loudness and distress. These findings suggest that daily self-reported data on tinnitus symptoms is sensitive to treatment response and provides insights into specific symptom changes that occur during treatment.
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