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IgM 中和流感病毒的机制。

Mechanisms of neutralization of influenza virus by IgM.

作者信息

Taylor H P, Dimmock N J

出版信息

J Gen Virol. 1985 Apr;66 ( Pt 4):903-7. doi: 10.1099/0022-1317-66-4-903.

DOI:10.1099/0022-1317-66-4-903
PMID:3981137
Abstract

IgM which neutralized influenza virus infectivity by over 99% prevented the attachment of only half the virus population to BHK cells at 37 degrees C. However, the half of the population that attached to cells was not internalized. Loss of infectivity brought about by IgM is thus totally different from that caused by neutralizing IgG which does not inhibit attachment or penetration.

摘要

能使流感病毒感染性中和超过99%的IgM,在37℃时仅能阻止一半病毒群体附着于BHK细胞。然而,附着于细胞的那一半病毒群体并未被内化。因此,IgM导致的感染性丧失与中和性IgG引起的感染性丧失完全不同,后者并不抑制附着或穿透。

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