人类神经病变中传导阻滞的病理基础。
The pathological basis of conduction block in human neuropathies.
作者信息
Feasby T E, Brown W F, Gilbert J J, Hahn A F
出版信息
J Neurol Neurosurg Psychiatry. 1985 Mar;48(3):239-44. doi: 10.1136/jnnp.48.3.239.
Abstract
Conduction block was detected in patients with neuropathy by measuring a decrease in the size of the compound muscle action potential of more than 20% on proximal versus distal stimulation of the peroneal, median or ulnar nerve in the absence of excess temporal dispersion of the potential. The teased fibre analyses of nerve biopsies from four patients with "definite" and six patients with "probable" conduction block and from seven patients with neuropathy but without conduction block were compared. All patients with conduction block had significant demyelination (X% demyelinated and remyelinated fibres = 50%) while those without conduction block did not (X = 5.0%). Demyelination is the pathological basis of conduction block in human neuropathies.
摘要
通过测量在腓总神经、正中神经或尺神经近端与远端刺激时复合肌肉动作电位大小下降超过20%，且电位不存在过度时间离散的情况，在神经病变患者中检测到传导阻滞。对4例“确诊”传导阻滞患者、6例“可能”传导阻滞患者以及7例有神经病变但无传导阻滞患者的神经活检进行了 teased 纤维分析比较。所有有传导阻滞的患者均有显著的脱髓鞘（脱髓鞘和再髓鞘化纤维的比例X = 50%），而无传导阻滞的患者则没有（X = 5.0%）。脱髓鞘是人类神经病变中传导阻滞的病理基础。
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