Kim Gyeong-Hwan, Son Jiwoong, Nam Jwa-Min
The Research Institute of Basic Sciences, Seoul National University, Gwanak-ro 1, Gwanak-gu, Seoul 08826, South Korea.
Department of Chemistry, Seoul National University, Gwanak-ro 1, Gwanak-gu, Seoul 08826, South Korea.
ACS Nano. 2025 Jan 28;19(3):2992-3007. doi: 10.1021/acsnano.4c14557. Epub 2025 Jan 15.
Surface-enhanced Raman scattering has been widely used for molecular/material characterization and chemical and biological sensing and imaging applications. In particular, plasmonic nanogap-enhanced Raman scattering (NERS) is based on the highly localized electric field formed within the nanogap between closely spaced metallic surfaces to more strongly amplify Raman signals than the cases with molecules on metal surfaces. Nanoparticle-based NERS offers extraordinarily strong Raman signals and a plethora of opportunities in sensing, imaging and many different types of biomedical applications. Despite its potential, several challenges still remain for NERS to be widely useful in real-world applications. This Perspective introduces various plasmonic nanogap configurations with nanoparticles, discusses key advances and critical challenges while addressing possible misunderstandings in this field, and provides future directions for NERS to generate stronger, more uniform, and stable signals over a large number of structures for practical applications.
表面增强拉曼散射已广泛应用于分子/材料表征以及化学和生物传感与成像应用。特别是，等离子体纳米间隙增强拉曼散射（NERS）基于紧密间隔的金属表面之间纳米间隙内形成的高度局域化电场，比分子在金属表面的情况更强烈地放大拉曼信号。基于纳米颗粒的NERS提供了极其强烈的拉曼信号，并在传感、成像和许多不同类型的生物医学应用中带来了大量机会。尽管具有潜力，但NERS要在实际应用中广泛有用仍存在一些挑战。本观点介绍了各种带有纳米颗粒的等离子体纳米间隙配置，讨论了关键进展和关键挑战，同时解决了该领域可能存在的误解，并为NERS提供了未来方向，以便在大量结构上产生更强、更均匀和稳定的信号用于实际应用。
