川崎病中粒细胞趋化性受损及循环免疫复合物增加。

Impaired granulocyte chemotaxis and increased circulating immune complexes in Kawasaki disease.

作者信息

Ono S, Onimaru T, Kawakami K, Hokonohara M, Miyata K

出版信息

J Pediatr. 1985 Apr;106(4):567-70. doi: 10.1016/s0022-3476(85)80073-1.

Abstract

Our study was carried out to clarify the changes in granulocyte functions and circulating immune complexes in 32 children with Kawasaki disease. Patients were divided into two groups, those with or without coronary aneurysm. In the group with coronary aneurysm, impairment of both granulocyte chemotaxis and phagocytosis was found, together with higher circulating immune complexes and normal intracellular killing activity. In the group without coronary aneurysm, impaired phagocytosis was observed, with normal granulocyte chemotaxis, circulating immune complexes, and intracellular killing activity. No correlation was observed between granulocyte chemotaxis and circulating immune complexes. Impairment of granulocyte chemotaxis and circulating immune complexes may yield pertinent information as to the degree of severity of vasculitis in Kawasaki disease.

摘要

我们开展这项研究的目的是阐明32例川崎病患儿的粒细胞功能和循环免疫复合物的变化。将患者分为两组，即有或无冠状动脉瘤的患者。在有冠状动脉瘤的组中，发现粒细胞趋化性和吞噬作用均受损，同时循环免疫复合物水平较高，而细胞内杀伤活性正常。在无冠状动脉瘤的组中，观察到吞噬作用受损，而粒细胞趋化性、循环免疫复合物和细胞内杀伤活性正常。未观察到粒细胞趋化性与循环免疫复合物之间存在相关性。粒细胞趋化性和循环免疫复合物的受损可能为川崎病血管炎的严重程度提供相关信息。