Sørensen Simon T, Messina Walter, Niemitz Lorenzo, O'Dowling Claire, Buszman Piotr, Andersson-Engels Stefan, Burke Ray
Biophotonics@Tyndall, IPIC, Tyndall National Institute, Lee Maltings, Dyke Parade, Cork, Ireland.
Centre for Research in Vascular Biology, APC Microbiome Ireland, University College Cork, Cork University Hospital, Cork, Ireland.
Biomed Opt Express. 2024 Dec 3;16(1):12-27. doi: 10.1364/BOE.543373. eCollection 2025 Jan 1.
Cardiovascular imaging with camera-on-tip endoscopes has the potential to provide physiologically relevant data on the tissue state and device placement that can improve clinical outcomes. In this work, we review the unmet clinical need for image-based cardiovascular diagnostics and guidance for minimally invasive procedures. We present a 7 Fr camera-on-tip endoscope with fibre-coupled multispectral illumination that includes methods for imaging in a blood-filled field of view (FOV). We demonstrate that the endoscope can be navigated from the femoral artery to cardiac regions such as the left atrium and left ventricle in a porcine model, where images of the cardiac walls are recorded. We further show that physiologically relevant parameters such as heart rate and respiration can be extracted from the images and that changes to tissue state can be inferred from the imaging data. Finally, a methodology for merging the imaging data with diffuse reflection spectroscopy (DRS) recorded through the optical fibre is outlined.
使用顶端带摄像头的内窥镜进行心血管成像，有潜力提供有关组织状态和设备放置的生理相关数据，从而改善临床结果。在这项工作中，我们回顾了基于图像的心血管诊断以及微创程序指导方面尚未满足的临床需求。我们展示了一款带有光纤耦合多光谱照明的7F顶端带摄像头的内窥镜，其中包括在充满血液的视野（FOV）中成像的方法。我们证明，在猪模型中，该内窥镜可以从股动脉导航至心脏区域，如左心房和左心室，并记录心脏壁的图像。我们进一步表明，可以从图像中提取诸如心率和呼吸等生理相关参数，并且可以从成像数据中推断出组织状态的变化。最后，概述了一种将成像数据与通过光纤记录的漫反射光谱（DRS）合并的方法。
